The Scientific Synergy Core (Core A) is the intellectual fulcrum of this research core center. It represents a low-cost high impact core which will dramatically strengthen the hearing, balance and chemical senses sciences at the University of Michigan and in the research community in the Michigan - Ohio region. Specifically, the core will promote scientific information exchange and scholarly discussions through regular contacts, further technology transfer to enhance research, aid principal investigators in the training of students, fellows and staff, and encourage new and increased collaboration through the formation of special interest groups. Within the P30 research cores the regular contacts between the principal investigators and key personnel of the cores will remain the customary avenue of communication. Going beyond these interactions, however, all students, fellows, and laboratory staff are included in the meetings of the interest groups of Core A and the annual meetings that we are proposing. Despite its ambitions of maintaining a multi-institutional synergy core. Core A does not add significantly to the P30 budget because of the proximity of all participating laboratories, which eliminates the necessity for any overnight stays and associated costs for meetings, discussions, or service training. The educational training aspect of the proposed P30 Core Center includes a ten-week summer internship program for deaf and hard-of-hearing students. These students are an underrepresented minority in NIDCD mission-related research. Their inclusion in the Scientific Synergy Core will address the problem at the undergraduate level at a time when these students make career choices. By providing this resource to them and to our investigators, we will build novel mentoring relationships and train the next generation of scientists from this underrepresented minority group. The intellectual interactions provided by this core will consolidate mentoring relationships, encourage collaborations, and through discussion, enhance the quality of our research, our grant applications and our publications.
These aims will aid the growth of young groups and make established ones more competitive in their attempts to obtain grant funding.

Public Health Relevance

The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Pfingst, Bryan E; Zhou, Ning; Colesa, Deborah J et al. (2015) Importance of cochlear health for implant function. Hear Res 322:77-88
Owen, John H; Hauff, Samantha J; Tang, Alice L et al. (2014) UM-SCC-103: a unique tongue cancer cell line that recapitulates the tumorigenic stem cell population of the primary tumor. Ann Otol Rhinol Laryngol 123:662-72
Takada, Yohei; Beyer, Lisa A; Swiderski, Donald L et al. (2014) Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy. Hear Res 309:124-35
Park, Yong-Ho; Wilson, Kevin F; Ueda, Yoshihisa et al. (2014) Conditioning the cochlea to facilitate survival and integration of exogenous cells into the auditory epithelium. Mol Ther 22:873-80
Le Prell, Colleen G; Dolan, David F; Hughes, Larry F et al. (2014) Disruption of lateral olivocochlear neurons with a dopaminergic neurotoxin depresses spontaneous auditory nerve activity. Neurosci Lett 582:54-8
Imtiaz, Ayesha; Kohrman, David C; Naz, Sadaf (2014) A frameshift mutation in GRXCR2 causes recessively inherited hearing loss. Hum Mutat 35:618-24
Micucci, Joseph A; Layman, Wanda S; Hurd, Elizabeth A et al. (2014) CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome. Hum Mol Genet 23:434-48
Rudnicki, Anya; Shivatzki, Shaked; Beyer, Lisa A et al. (2014) microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation. Hum Mol Genet 23:3138-46
Zhou, Ning; Pfingst, Bryan E (2014) Effects of site-specific level adjustments on speech recognition with cochlear implants. Ear Hear 35:30-40
Zhou, Ning; Pfingst, Bryan E (2014) Relationship between multipulse integration and speech recognition with cochlear implants. J Acoust Soc Am 136:1257

Showing the most recent 10 out of 193 publications