The Physiology Core will provide critical support for assessment of function through four aims.
Aim 1 : Enhance and extend the quality and scope of the individual research projects: The Core will provide and facilitate application of methods and approaches that are not within the expertise of individual investigators but can address hypotheses in their studies. The most common assessment is of auditory brain stem response (ABR) with more in-depth measures, e.g. otoacoustic emissions, efferent reflex, round window noise, cochlear microphonics, cochlear whole-nerve action potentials and endolymphatic potential also available. The Core also develops conditions for and coordinates noise exposures of animals.
Aim 2 : Improve the efficiency and productivity of ongoing research within the user group: The Core will provide centralized, well maintained equipment and facilities and shared resources for various physiological measurements. It will also provide training of students, fellows and staff in the basic methods (for example ABR), avoiding pitfalls and facilitating accurate interpretation of results. Expert staff will perform and/or assist in measurement of complex physiological functions.
Aim 3 : Develop methods and approaches to meet current and anticipated user needs: The Core will work with individual investigators to modify and develop applications and contribute to experimental design to select most appropriate physiological parameters. The Core will now offer a new screen to test basic vestibular function developed by Dr. King (consultant) to meet needs of our user base.
Aim 4 : Provide education, develop interactions and new collaborations: The Core will continue to train students, fellows and staff in routine procedures and facilitate adoption of new ones. Meetings with faculty, students and staff provide a forum for education and information on novel and advanced methodologies as do presentations at the regularly scheduled larger group meetings of Core A (Scientific Synergy Core). The Physiology Core also aids in the interpretation and the preparation of results for publications. Together with the Cell and Molecular Biology Core (Core C), the Physiology Core provides an essential link of genetic, molecular and biochemical data to structure and function.
The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.
|Choo, Daniel I; Tawfik, Kareem O; Martin, Donna M et al. (2017) Inner ear manifestations in CHARGE: Abnormalities, treatments, animal models, and progress toward treatments in auditory and vestibular structures. Am J Med Genet C Semin Med Genet 175:439-449|
|Yang, Chao-Hui; Liu, Zhiqi; Dong, Deanna et al. (2017) Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity. Front Cell Neurosci 11:315|
|Walline, Heather M; Goudsmit, Christine M; McHugh, Jonathan B et al. (2017) Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines. Head Neck 39:840-852|
|Schaefer, Stacy A; Higashi, Atsuko Y; Loomis, Benjamin et al. (2017) From otic induction to hair cell production: Pax2EGFP cell line illuminates key stages of development in mouse inner ear organoid model. Stem Cells Dev :|
|Munnamalai, Vidhya; Sienknecht, Ulrike J; Duncan, R Keith et al. (2017) Wnt9a Can Influence Cell Fates and Neural Connectivity across the Radial Axis of the Developing Cochlea. J Neurosci 37:8975-8988|
|Schvartz-Leyzac, Kara C; Pfingst, Bryan E (2017) Assessing the Relationship Between the Electrically Evoked Compound Action Potential and Speech Recognition Abilities in Bilateral Cochlear Implant Recipients. Ear Hear :|
|Morley, Barbara J; Dolan, David F; Ohlemiller, Kevin K et al. (2017) Generation and Characterization of ?9 and ?10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background. Front Neurosci 11:516|
|Pfingst, Bryan E; Colesa, Deborah J; Swiderski, Donald L et al. (2017) Neurotrophin Gene Therapy in Deafened Ears with Cochlear Implants: Long-term Effects on Nerve Survival and Functional Measures. J Assoc Res Otolaryngol 18:731-750|
|Schvartz-Leyzac, Kara C; Zwolan, Teresa A; Pfingst, Bryan E (2017) Effects of electrode deactivation on speech recognition in multichannel cochlear implant recipients. Cochlear Implants Int 18:324-334|
|Klimpel, Katarina E M; Lee, Min Young; King, W. Michael et al. (2017) Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment. Environ Toxicol 32:869-876|
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