This application requests support to continue the productive work of the University of Michigan Cell &Molecular Biology (CMB) Core to enhance NIDCD-mission oriented research. The proposal builds on experience gained from the two previous P30 grant periods The Cell &Molecular Biology (CMB) Core will continue to serve the user base through its four aims:
Aim 1 : Enhance and extend the quality and scope of the individual research projects of Core participants Aim 2: Improve efficiency and productivity of research within the user group Aim 3: Develop methods and approaches to meet current user needs and to anticipate future needs Aim 4: Provide education, develop collaborations and bring new people into the field New to the next five years, the CMB Core is adding processing and assessment of vestibular tissues and tissues associated with the chemical senses, to reflect the needs of the user base. Dr. Kohrman is replacing Dr. Lomax as the co-Director and the molecular biology consultation offered can expand to include information on developing and using transgenic mice. The CMB will continue to bring new methods and approaches to individual investigators and develop technology, data bases and shared resources. It will provide information on new advances in methodology to individual investigators, train staff of individual investigators in both routine and novel molecular methodologies and provide a bridge to centralized University of Michigan facilities for novel and advanced methodologies. It will provide state-of-the-art support for morphological and molecular assessments, provide normative data bases and provide assistance in experimental design and interpretation of results. It will use the Scientific Synergy Core and periodic meetings with qualified users to present new methods and approaches, share experiences, problems and successes and develop new productive collaborations. The CMB services and presentations will continue to bring new investigators to the study of hearing, balance and chemical senses research. The CMB Core will also work closely with the Physiology Core to coordinate physiological, behavioral, morphological and molecular characterization of animals to enhance our understanding of hearing, balance and chemical senses and to define molecular interventions that will prevent and treat their disorders.
The purpose of this grant is to enhance and extend the research of multiple investigators towards increasing the understanding of disorders of hearing, balance, taste and smell and developing the ability to prevent and treat these disorders. It will also provide mechanisms to encourage and increase collaborations among its research base, bring new researchers into the field as well as educate the user base on new methods and approaches.
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|Owen, John H; Hauff, Samantha J; Tang, Alice L et al. (2014) UM-SCC-103: a unique tongue cancer cell line that recapitulates the tumorigenic stem cell population of the primary tumor. Ann Otol Rhinol Laryngol 123:662-72|
|Takada, Yohei; Beyer, Lisa A; Swiderski, Donald L et al. (2014) Connexin 26 null mice exhibit spiral ganglion degeneration that can be blocked by BDNF gene therapy. Hear Res 309:124-35|
|Park, Yong-Ho; Wilson, Kevin F; Ueda, Yoshihisa et al. (2014) Conditioning the cochlea to facilitate survival and integration of exogenous cells into the auditory epithelium. Mol Ther 22:873-80|
|Le Prell, Colleen G; Dolan, David F; Hughes, Larry F et al. (2014) Disruption of lateral olivocochlear neurons with a dopaminergic neurotoxin depresses spontaneous auditory nerve activity. Neurosci Lett 582:54-8|
|Imtiaz, Ayesha; Kohrman, David C; Naz, Sadaf (2014) A frameshift mutation in GRXCR2 causes recessively inherited hearing loss. Hum Mutat 35:618-24|
|Micucci, Joseph A; Layman, Wanda S; Hurd, Elizabeth A et al. (2014) CHD7 and retinoic acid signaling cooperate to regulate neural stem cell and inner ear development in mouse models of CHARGE syndrome. Hum Mol Genet 23:434-48|
|Rudnicki, Anya; Shivatzki, Shaked; Beyer, Lisa A et al. (2014) microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation. Hum Mol Genet 23:3138-46|
|Zhou, Ning; Pfingst, Bryan E (2014) Effects of site-specific level adjustments on speech recognition with cochlear implants. Ear Hear 35:30-40|
|Zhou, Ning; Pfingst, Bryan E (2014) Relationship between multipulse integration and speech recognition with cochlear implants. J Acoust Soc Am 136:1257|
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