A. Abstract and Key Personnel Three Research Cores are proposed to facilitate interdisciplinary research into hearing and deafness at the Massachusetts Eye and Ear Infirmary. The three Cores and the major aims of each include 1) an Engineering Core to design, build, program and maintain data-acquisition systems, custom acoustical devices, and stimulus generation systems, and to provide a precision machining service to build custom mechanical devices for a wide variety of research applications;2) an Imaging Core to support the needs of Center investigators for digital image-acquisition and analysis, including confocal microscopy, transmission electron microscopy, computer-aided anatomical reconstruction, automation of morphometry, 3-D reconstruction/rendering, and analysis of functional imaging data;and 3) a Histology-Surgery Core to maintain existing shared facilities and assist research teams in animal surgery and histological preparation for both light and electron microscopy. The Administrative Shell for this P30 includes the Program Director and a Grants Manager. Only fractional additional effort level is required to effectively administer this P30, because 1) the Center Investigators, Core Personnel, Program Director and Grants Manager have a long history of productive collaboration, 2) the Program Director is also Co-PI on both Imaging and Histology-Surgery Cores and is an active user of the Engineering Core, and 3) the Grants Manager also handles many pre-award and postaward functions for the numerous R-grants of almost all Center Investigators and is thus thoroughly conversant with all the components of this Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005209-13
Application #
8662226
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
Chung, Yoojin; Hancock, Kenneth E; Delgutte, Bertrand (2016) Neural Coding of Interaural Time Differences with Bilateral Cochlear Implants in Unanesthetized Rabbits. J Neurosci 36:5520-31
Suzuki, Jun; Corfas, Gabriel; Liberman, M Charles (2016) Round-window delivery of neurotrophin 3 regenerates cochlear synapses after acoustic overexposure. Sci Rep 6:24907
Knudson, Inge M; Melcher, Jennifer R (2016) Elevated Acoustic Startle Responses in Humans: Relationship to Reduced Loudness Discomfort Level, but not Self-Report of Hyperacusis. J Assoc Res Otolaryngol 17:223-35
Nam, Hui; Guinan Jr, John J (2016) Low-frequency bias tone suppression of auditory-nerve responses to low-level clicks and tones. Hear Res 341:66-78
Valero, Michelle D; Hancock, Kenneth E; Liberman, M Charles (2016) The middle ear muscle reflex in the diagnosis of cochlear neuropathy. Hear Res 332:29-38
Tong, Benton; Hornak, Aubrey J; Maison, Stéphane F et al. (2016) Oncomodulin, an EF-Hand Ca2+ Buffer, Is Critical for Maintaining Cochlear Function in Mice. J Neurosci 36:1631-5
Kempfle, Judith S; Turban, Jack L; Edge, Albert S B (2016) Sox2 in the differentiation of cochlear progenitor cells. Sci Rep 6:23293
Liberman, Leslie D; Liberman, M Charles (2016) Postnatal maturation of auditory-nerve heterogeneity, as seen in spatial gradients of synapse morphology in the inner hair cell area. Hear Res 339:12-22
Hu, Lingxiang; Lu, Jingrong; Chiang, Hao et al. (2016) Diphtheria Toxin-Induced Cell Death Triggers Wnt-Dependent Hair Cell Regeneration in Neonatal Mice. J Neurosci 36:9479-89
Day, Mitchell L; Delgutte, Bertrand (2016) Neural population encoding and decoding of sound source location across sound level in the rabbit inferior colliculus. J Neurophysiol 115:193-207

Showing the most recent 10 out of 158 publications