This is the application for competing renewal of P30 DC005211, """"""""Sensory Mechanisms Research Core"""""""" to provide shared services to a group of NIDCD-funded laboratories. The proposal includes an Administrative Shell, Engineering and Histology Cores. These Research Cores will enable more efficient utilization of common services, as well as access to specialized expertise. The Engineering Core includes a senior programmer and electronics technician, central data servers, auditory phenotyping facility, design of advanced acoustic stimuli and analyses, and a large-format poster printer. The Histology Core offers support and training in tissue preparation for standard light microscopy and immunofluorescence. In addition the Histology Core supports a senior EM microscopist, ultramicrotomy and EM access, as well as trained histologists to guide confocal imaging. The Histology Core will incorporate a confocal microscope into the shared facilities. Together the Engineering and Histology Cores, organized through the Administrative Shell, further strengthen the Center for Hearing and Balance, and now the Center for Sensory Biology which includes NIDCD-funded laboratories studying chemical senses at Johns Hopkins.

Public Health Relevance

The Center for Hearing and Balance, and the Center for Sensory Biology (including chemical senses) at Johns Hopkins together incorporate nearly all the NIDCD-funded research laboratories. Thus this P30 is highly relevant to the scientific goals of studying deafness and other communication disorders. These research Centers are closely allied with clinical investigators in Otolaryngology-Head and Neck Surgery, and Neurology. Core B Engineering Core Director: Eric Young, Ph.D. Co-Director: Bradford May, Ph.D. DESCRIPTION (provided by applicant): A rate-limiting step for many studies of the nervous system is obtaining and effectively using the sophisticated technical hardware and analytical methods needed for innovative research. These constraints apply as well to studies of neural signal processing in the brain as they do to studies of disordered processing in animal models of hearing or balance deficits. Even if hardware/software systems are available for planned experiments, they inevitably require modification for special purposes or integration with other systems in the laboratory. This Engineering Core aims to solve these electronics and computer problems by providing computer programming and electronics expertise to researchers in the Center for Hearing and Balance. The cumulative expertise of our staff makes it possible for our research faculty to focus on experiments and not technology development and allows rapid progress in the use of new technologies. During the past five years this core has developed new behavioral interfaces, new telemetric recording equipment for use in awake and unrestrained animals, and new software for on-line optimization of neuron models. We have adapted multi-single unit recording techniques for our uses and have provided support for routine problems of technology usage.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005211-13
Application #
8716718
Study Section
Special Emphasis Panel (ZDC1)
Program Officer
Platt, Christopher
Project Start
2002-02-01
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wu, Jingjing Sherry; Young, Eric D; Glowatzki, Elisabeth (2016) Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations. J Neurosci 36:10584-10597
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Campbell, Dean P; Chrysostomou, Elena; Doetzlhofer, Angelika (2016) Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep 6:19484
Martinez-Monedero, Rodrigo; Liu, Chang; Weisz, Catherine et al. (2016) GluA2-Containing AMPA Receptors Distinguish Ribbon-Associated from Ribbonless Afferent Contacts on Rat Cochlear Hair Cells. eNeuro 3:
Hageman, Kristin N; Kalayjian, Zaven K; Tejada, Francisco et al. (2016) A CMOS Neural Interface for a Multichannel Vestibular Prosthesis. IEEE Trans Biomed Circuits Syst 10:269-79
Lin, Chun-Chieh; Potter, Christopher J (2016) Editing Transgenic DNA Components by Inducible Gene Replacement in Drosophila melanogaster. Genetics 203:1613-28
Abt, Nicholas B; Lehar, Mohamed; Guajardo, Carolina Trevino et al. (2016) Intratympanic Iodine Contrast Injection Diffuses Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging. Otol Neurotol 37:403-7
Lin, Chun-Chieh; Potter, Christopher J (2016) Non-Mendelian Dominant Maternal Effects Caused by CRISPR/Cas9 Transgenic Components in Drosophila melanogaster. G3 (Bethesda) :
Diao, Fengqiu; Ironfield, Holly; Luan, Haojiang et al. (2015) Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes. Cell Rep 10:1410-21
Ward, Bryan K; Roberts, Dale C; Della Santina, Charles C et al. (2015) Vestibular stimulation by magnetic fields. Ann N Y Acad Sci 1343:69-79

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