A variety of research projects within the Core-Center employ human subjects. The Human Subjects Core (HSC) greatly facilitates our collective research goals by centralizing a set of common procedures, operated by a seasoned staff that interact effectively with both the subjects and with faculty, students, and laboratory staff within the research studies supported by the Core. The Core provides several key services. First, the Core coordinates recruitment and screening of human subjects across research projects (normal and patient). This includes identifying subjects and obtaining informed consent, followed by basic medical and sensorimotor/neurologic exams, as well as physiologic and cognitive screening relevant to the populations targeted by Core studies. Populations now under study include normal subjects across a broad range of ages, subjects with specific neurological disorders (e.g. inherited ataxias, Alzheimer's and other degenerative diseases), and subjects with specific sensory loss (hearing, vision, vestibular), but otherwise healthy. Second, the Core coordinates scheduling and tracking across projects in order to maximize efficiency and convenience for subjects, investigators and staff. Further, the use of common subjects across studies supplies novel and paired observations that enhance productivity and stimulate new and collaborative research. Third, the Core maintains a powerful modern database that provides protected access to data and analytic tools for investigators and staff. This central service promotes new studies while making existing ones more efficient. Fourth, Core services include the coordination of protocol approvals, staff credential ing, and record keeping required of all human studies. The above services and tasks are made exceedingly efficient by a centralized structure orchestrated by a seasoned and trained staff. The benefits unload time and effort for faculty and staff to pursue more directly relevant research goals, and simultaneously catalyze new projects and collaborations. This is apparent in the growth of human studies in the Core-Center, including those by new faculty and ongoing ones alike.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1-SRB-L)
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University of Rochester
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Parks, Xiaorong Xu; Contini, Donatella; Jordan, Paivi M et al. (2017) Confirming a Role for ?9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista. Front Cell Neurosci 11:356
Bosen, Adam K; Fleming, Justin T; Allen, Paul D et al. (2017) Accumulation and decay of visual capture and the ventriloquism aftereffect caused by brief audio-visual disparities. Exp Brain Res 235:585-595
Bennetto, Loisa; Keith, Jessica M; Allen, Paul D et al. (2017) Children with autism spectrum disorder have reduced otoacoustic emissions at the 1 kHz mid-frequency region. Autism Res 10:337-345
Holt, J Chris; Jordan, Paivi M; Lysakowski, Anna et al. (2017) Muscarinic Acetylcholine Receptors and M-Currents Underlie Efferent-Mediated Slow Excitation in Calyx-Bearing Vestibular Afferents. J Neurosci 37:1873-1887
Bosen, Adam K; Fleming, Justin T; Brown, Sarah E et al. (2016) Comparison of congruence judgment and auditory localization tasks for assessing the spatial limits of visual capture. Biol Cybern 110:455-471
Miller, Mark A; Crane, Benjamin T (2016) Static and dynamic visual vertical perception in subjects with migraine and vestibular migraine. World J Otorhinolaryngol Head Neck Surg 2:175-180
Karcz, Anita; Allen, Paul D; Walton, Joseph et al. (2015) Auditory deficits of Kcna1 deletion are similar to those of a monaural hearing impairment. Hear Res 321:45-51
Miller, Mark A; O'Leary, Catherine J; Allen, Paul D et al. (2015) Human Vection Perception Using Inertial Nulling and Certainty Estimation: The Effect of Migraine History. PLoS One 10:e0135335
Holt, J Chris; Kewin, Kevin; Jordan, Paivi M et al. (2015) Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. J Neurosci 35:3625-43
Jordan, Paivi M; Fettis, Margaret; Holt, Joseph C (2015) Efferent innervation of turtle semicircular canal cristae: comparisons with bird and mouse. J Comp Neurol 523:1258-80

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