The Increase in powerful molecular and genetic tools for Investigation of gene function in the laboratory mouse has greatly increased Interest in this animal as a model for auditory and vestibular research. Although the interpretation of experiments exploiting mice with genetic alterations is not always straightforward, the ability to examine the consequences of modification of a single gene has tremendous implications for molecular investigation of the inner ear. The overall goal of the Mouse Core Is to enable Investigators In the Core Center to carry out experiments with mice, and in particular with genetically modified mice. This ability should enhance present research projects and lead to new experimental approaches, particularly involving collaborations among several Investigators. To provide expertise and services to the Core Center for mouse molecular genetics studies, three specific aims are proposed: 1. To provide mouse husbandry services and training, 2. To provide genotyping services and training, and 3. To provide in utero gene transfer resources. Our service approach is to centralize these activities in a single facility. The model allows individual investigators to focus on their specific research projects while enjoying a more cost-effective model for the use of mice in their NIDCD-funded research programs.

Public Health Relevance

This P30 Core Center supports 20 Investigators who carry out research into the basic and disease mechanisms of hearing, balance, and smell. The Mouse Core facilitates many of these research programs by offering support in raising mice and carrying out experiments where exogenous DNA is used to direct expression of proteins in a variety of cell types in both the central and peripheral auditory systems.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC005983-12
Application #
8701272
Study Section
Special Emphasis Panel (ZDC1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
12
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
97239
Krey, Jocelyn F; Dumont, Rachel A; Wilmarth, Philip A et al. (2018) ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci 38:843-857
Reiss, Lina A J; Fowler, Jennifer R; Hartling, Curtis L et al. (2018) Binaural Pitch Fusion in Bilateral Cochlear Implant Users. Ear Hear 39:390-397
Wang, Lingyan; Kempton, J Beth; Brigande, John V (2018) Gene Therapy in Mouse Models of Deafness and Balance Dysfunction. Front Mol Neurosci 11:300
Oh, Yonghee; Reiss, Lina A J (2018) Binaural Pitch Fusion: Effects of Amplitude Modulation. Trends Hear 22:2331216518788972
Kachelmeier, Allan; Shola, Tsering; Meier, William B et al. (2018) Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells. PLoS One 13:e0206628
Reiss, Lina A J; Shayman, Corey S; Walker, Emily P et al. (2017) Binaural pitch fusion: Comparison of normal-hearing and hearing-impaired listeners. J Acoust Soc Am 141:1909
Erickson, Timothy; Morgan, Clive P; Olt, Jennifer et al. (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife 6:
Krey, J F; Wilmarth, P A; David, L L et al. (2017) Analysis of the Proteome of Hair-Cell Stereocilia by Mass Spectrometry. Methods Enzymol 585:329-354
Adler, Henry J; Anbuhl, Kelsey L; Atcherson, Samuel R et al. (2017) Community network for deaf scientists. Science 356:386-387
Oh, Yonghee; Reiss, Lina A J (2017) Binaural pitch fusion: Pitch averaging and dominance in hearing-impaired listeners with broad fusion. J Acoust Soc Am 142:780

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