The Increase in powerful molecular and genetic tools for Investigation of gene function in the laboratory mouse has greatly increased Interest in this animal as a model for auditory and vestibular research. Although the interpretation of experiments exploiting mice with genetic alterations is not always straightforward, the ability to examine the consequences of modification of a single gene has tremendous implications for molecular investigation of the inner ear. The overall goal of the Mouse Core Is to enable Investigators In the Core Center to carry out experiments with mice, and in particular with genetically modified mice. This ability should enhance present research projects and lead to new experimental approaches, particularly involving collaborations among several Investigators. To provide expertise and services to the Core Center for mouse molecular genetics studies, three specific aims are proposed: 1. To provide mouse husbandry services and training, 2. To provide genotyping services and training, and 3. To provide in utero gene transfer resources. Our service approach is to centralize these activities in a single facility. The model allows individual investigators to focus on their specific research projects while enjoying a more cost-effective model for the use of mice in their NIDCD-funded research programs.

Public Health Relevance

This P30 Core Center supports 20 Investigators who carry out research into the basic and disease mechanisms of hearing, balance, and smell. The Mouse Core facilitates many of these research programs by offering support in raising mice and carrying out experiments where exogenous DNA is used to direct expression of proteins in a variety of cell types in both the central and peripheral auditory systems.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1)
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Oregon Health and Science University
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Reiss, Lina A J; Ito, Rindy A; Eggleston, Jessica L et al. (2015) Pitch adaptation patterns in bimodal cochlear implant users: over time and after experience. Ear Hear 36:e23-34
MacArthur, Carol J; Wilmot, Beth; Wang, Linda et al. (2014) Genetic susceptibility to chronic otitis media with effusion: candidate gene single nucleotide polymorphisms. Laryngoscope 124:1229-35
Avenarius, Matthew R; Saylor, Katherine W; Lundeberg, Megan R et al. (2014) Correlation of actin crosslinker and capper expression levels with stereocilia growth phases. Mol Cell Proteomics 13:606-20
Krey, Jocelyn F; Wilmarth, Phillip A; Shin, Jung-Bum et al. (2014) Accurate label-free protein quantitation with high- and low-resolution mass spectrometers. J Proteome Res 13:1034-44
Maeda, Reo; Kindt, Katie S; Mo, Weike et al. (2014) Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2. Proc Natl Acad Sci U S A 111:12907-12
Wilson, Teresa; Omelchenko, Irina; Foster, Sarah et al. (2014) JAK2/STAT3 inhibition attenuates noise-induced hearing loss. PLoS One 9:e108276
Detwiller, Kara Y; Smith, Timothy L; Alt, Jeremiah A et al. (2014) Differential expression of innate immunity genes in chronic rhinosinusitis. Am J Rhinol Allergy 28:374-7
Reiss, Lina A J; Ito, Rindy A; Eggleston, Jessica L et al. (2014) Abnormal binaural spectral integration in cochlear implant users. J Assoc Res Otolaryngol 15:235-48
Apostolides, Pierre F; Trussell, Laurence O (2014) Superficial stellate cells of the dorsal cochlear nucleus. Front Neural Circuits 8:63
Jiang, Meiyan; Wang, Qi; Karasawa, Takatoshi et al. (2014) Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides. PLoS One 9:e108941

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