Our primary goal is to provide centralized and high-quality support for both basic and customized computing and engineering Service and training that can not only increase collaboration, efficiency and quality of existing research, but also stimulate new research in NIDCD mission areas at the University of California Irvine (UCI) and beyond. Our overall research strategy is to build upon and expand the service and support in computing arid engineering, according to the requests of the past, current and future core users with diverse backgrounds and needs. We have identified several common threads and developed signal processing tools, customized sound control, and formalized training to address these diverse backgrounds and needs. The present renewal application seeks to achieve the following three specific alms.
Aim 1 will provide signal processing the popular support for core users in stimulus generation and data processing.
Aim 2 will provide customized support for core users in sound control and prototype development. A highlight in Aim is collaboration with the Imaging core to build and integrate an ABR recording capability to be housed in the two-photo imaging facility.
Aim 3 will provide network and education support for core users and the hearing research community.

Public Health Relevance

The proposed core activities are relevant to public health because they not only increase the efficiency and impact of innovative science performed by its users but also directly support translational research and education through prototype development and training. A significant goal of the present renewal is to increase the core's online presence, making signal processing tools and training materials available to researchers, clinicians, and the general public.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1)
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University of California Irvine
United States
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Cramer, K S; Gabriele, M L (2014) Axon guidance in the auditory system: multiple functions of Eph receptors. Neuroscience 277:152-62
Zeng, Fan-Gang; Tang, Qing; Lu, Thomas (2014) Abnormal pitch perception produced by cochlear implant stimulation. PLoS One 9:e88662
Lu, Thomas; Huang, Juan; Zeng, Fan-Gang (2014) Accurate guitar tuning by cochlear implant musicians. PLoS One 9:e92454
Mc Laughlin, Myles; Reilly, Richard B; Zeng, Fan-Gang (2013) Rate and onset cues can improve cochlear implant synthetic vowel recognition in noise. J Acoust Soc Am 133:1546-60
Nakamura, Paul A; Cramer, Karina S (2013) EphB2 signaling regulates lesion-induced axon sprouting but not critical period length in the postnatal auditory brainstem. Neural Dev 8:2
Kawai, Hideki D; La, Maggie; Kang, Ho-An et al. (2013) Convergence of nicotine-induced and auditory-evoked neural activity activates ERK in auditory cortex. Synapse 67:455-68
Yang, Hsin-I; Zeng, Fan-Gang (2013) Reduced acoustic and electric integration in concurrent-vowel recognition. Sci Rep 3:1419
Wynne, Dwight P; Zeng, Fan-Gang; Bhatt, Shrutee et al. (2013) Loudness adaptation accompanying ribbon synapse and auditory nerve disorders. Brain 136:1626-38
Guo, Fei; Intskirveli, Irakli; Blake, David T et al. (2013) Tone-detection training enhances spectral integration mediated by intracortical pathways in primary auditory cortex. Neurobiol Learn Mem 101:75-84
Lin, Payton; Lu, Thomas; Zeng, Fan-Gang (2013) Central masking with bilateral cochlear implants. J Acoust Soc Am 133:962-9

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