The proposed Center for Molecular Auditory Neuroscience will enhance productivity, innovation, and collaborative interactions of auditory researchers at the University of Iowa. Center investigators are members of five clinical and basic science departments: Otolaryngology, Biology, Biochemistry, Physiology, and Communication Sciences and Disorders, with 15 auditory-related R01s, nine funded by NIDCD, a P50, two T32s, and other grants, for a total current year direct cost >$9M. There are extensive interactions among basic researchers, among clinical researchers, and interactions bridging clinical and basic research. The cores aim to strengthen these interactions and develop new ones. The Center consists of three research cores and will provide first-rate facilities for state-of-the-art experimental techniques crucial to molecular, cell, developmental and neurobiology of the inner ear;provide training in these techniques;make investigators aware of alternative experimental approaches and model systems that will facilitate their research;foster new collaborations that result in innovative approaches to problems in auditory research, including translation of basic research data to the clinic. The research cores are: (1) Histology and Imaging core to provide facilities and training for analysis of model organisms using light microscopy and EM: histology, including sectioning, staining, immunofluorescence, EM, and use of fluorescent dyes to label nerve fibers;confocal imaging, including multiphoton, of live or fixed tissue;(2) Genomics core for routine molecular biology techniques - sequencing, nucleotide synthesis, nucleic acid quantitation and quality - as well as analysis of gene expression;(3) Tissue/Cell Culture Core to provide facilities and training for preparation of in vitro cochlear model systems including sensory, neural and glial cells, organotypic inner ear cultures, and means for gene transfer into these cells. Individual experiments may use multiple cores and workflow will be coordinated among Core directors. The Administrative Core will manage day-to-day operation of the Center, coordinate activities of Core directors, and conduct symposia and seminars to facilitate interaction among the Center investigators.

Public Health Relevance

This P30 will support research interactions among a diverse group of investigators engaged in related questions of basic and clinical research: deafness genetics and gene therapy, inner ear development, sensorineural cell function and maintenance, cochlear implants. These are fundamental to prevention of deafness, optimization of current treatment of deafness, and to future cochlear sensorineural regeneration.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC010362-04
Application #
8528540
Study Section
Special Emphasis Panel (ZDC1-SRB-Q (68))
Program Officer
Platt, Christopher
Project Start
2010-09-01
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$394,465
Indirect Cost
$133,230
Name
University of Iowa
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Fritzsch, Bernd; Pan, Ning; Jahan, Israt et al. (2015) Inner ear development: building a spiral ganglion and an organ of Corti out of unspecified ectoderm. Cell Tissue Res 361:24-Jul
Fritzsch, Bernd; Jahan, Israt; Pan, Ning et al. (2015) Evolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system. Cell Tissue Res 359:295-313
Tuft, Bradley W; Xu, Linjing; White, Scott P et al. (2014) Neural pathfinding on uni- and multidirectional photopolymerized micropatterns. ACS Appl Mater Interfaces 6:11265-76
Ahmad, Iram; Yue, Wei Ying; Fernando, Augusta et al. (2014) p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor ?B. Glia 62:1699-712
Swiderski, Ruth E; Nakano, Yoko; Mullins, Robert F et al. (2014) A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet 10:e1004689
Boekhoff-Falk, Grace; Eberl, Daniel F (2014) The Drosophila auditory system. Wiley Interdiscip Rev Dev Biol 3:179-91
Bailey, Erin M; Green, Steven H (2014) Postnatal expression of neurotrophic factors accessible to spiral ganglion neurons in the auditory system of adult hearing and deafened rats. J Neurosci 34:13110-26
Mao, YanYan; Reiprich, Simone; Wegner, Michael et al. (2014) Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear. PLoS One 9:e94580
Christie, Kevin W; Eberl, Daniel F (2014) Noise-induced hearing loss: new animal models. Curr Opin Otolaryngol Head Neck Surg 22:374-83
Inagaki, Akira; Frank, C Andrew; Usachev, Yuriy M et al. (2014) Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²? channel due to a familial hemiplegic migraine mutation. Neuron 81:91-102

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