The main goals of the Stanford OHNS Core Center are to serve 1) as a hub for knowledge and technology, 2) to stimulate and support collaborative research, and 3) to provide access to high quality state-of-the-art technology via cost efficient shared utilization of Core Center equipment among R01-funded laboratories. Administration of the Core Center will be provided by the Principal Investigator and two Research Core Directors in conjunction with an administrative assistant. The Core's administration is responsible for daily operations, but also for long-term planning with the overall objective to ensure that the main goals of the Core Center are being met. Two Research Cores are proposed: Core I - Imaging Core, consists of four independent imaging systems, each one individually dedicated for specific tasks including routine confocal and fluorescence imaging, two photon imaging, live cell confocal imaging, and high-speed live cell confocal imaging. A full time imaging specialist will support Core users with expert advice, training, and supervision. Core II - Auditory Function Core consists of dedicated apparatus development space, two sound shielded rooms, two adjacent rooms for animal preparations and recovery, and three comprehensive auditory physiology systems. These systems are dedicated to measures of auditory function in vivo in small mammals including tympanometry, otoacoustic emissions and auditory evoked potentials from surface or subdural electrodes. A part time auditory function specialist will support core users with expertise, training, and supervision. The imaging and auditory function equipment is already being used by a group of researchers that are faculty members in Otolaryngology - Head &Neck Surgery, Neurobiology, Molecular &Cellular Physiology, as well as Bioengineering. There already is an urgent need for support personnel and an overall core organization, which will ensure efficient shared use of the existing equipment by a highly collaborative user base that is unified by a common interest in auditory and vestibular neurobiology.

Public Health Relevance

The Core Center at Stanford Otolaryngology - Head &Neck Surgery aims to support the research endeavors of a central group of 11 Principal Investigators working on topics related to auditory and vestibular neurobiology. It is meant to generate a central hub of knowledge, technology, and collaboration for R01- funded basic researchers as well as clinicians, thereby spawning new ideas and translational advances.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC010363-04
Application #
8308577
Study Section
Special Emphasis Panel (ZDC1-SRB-Q (64))
Program Officer
Platt, Christopher
Project Start
2009-09-18
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$456,347
Indirect Cost
$171,130
Name
Stanford University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Ealy, Megan; Ellwanger, Daniel C; Kosaric, Nina et al. (2016) Single-cell analysis delineates a trajectory toward the human early otic lineage. Proc Natl Acad Sci U S A 113:8508-13
Lee, Hee Yoon; Raphael, Patrick D; Xia, Anping et al. (2016) Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti. J Neurosci 36:8160-73
Zeng, Wei-Zheng; Grillet, Nicolas; Dewey, James B et al. (2016) Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function. J Neurosci 36:9201-16
Sundaresan, Srividya; Kong, Jee-Hyun; Fang, Qing et al. (2016) Thyroid hormone is required for pruning, functioning and long-term maintenance of afferent inner hair cell synapses. Eur J Neurosci 43:148-61
Sundaresan, S; Balasubbu, S; Mustapha, M (2016) Thyroid hormone is required for the pruning of afferent type II spiral ganglion neurons in the mouse cochlea. Neuroscience 312:165-78
Xia, Anping; Liu, Xiaofang; Raphael, Patrick D et al. (2016) Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla. Nat Commun 7:13133
Kim, Sangmin; Raphael, Patrick D; Oghalai, John S et al. (2016) High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography. Biomed Opt Express 7:1430-44
Durruthy-Durruthy, Robert; Heller, Stefan (2015) Applications for single cell trajectory analysis in inner ear development and regeneration. Cell Tissue Res 361:49-57
Huth, Markus E; Han, Kyu-Hee; Sotoudeh, Kayvon et al. (2015) Designer aminoglycosides prevent cochlear hair cell loss and hearing loss. J Clin Invest 125:583-92
Lee, Hee Yoon; Raphael, Patrick D; Park, Jesung et al. (2015) Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea. Proc Natl Acad Sci U S A 112:3128-33

Showing the most recent 10 out of 55 publications