The P30 Core Center of the Monell Chemical Senses Center serves a Research Base of nine PIs with sixteen active ROI grants in the NIDCD mission area by providing expertise in the following areas: 1. Histology, 2. Genotyping, 3. Phenotyping. This P30 grant budgetary revision requests funds to support a new Research Core with a focus on Chemosensory Receptor Signaling. The new Chemosensory Receptor Signaling Core will be led jointly by Dr. Bedrich Mosinger (Director), an expert in the use of transgenic and knockout mouse models to study taste receptor genes, and Dr. Joel Mainland (Co-Director), an expert in high throughput analysis of odorant receptor genes in vitro. The Chemosensory Receptor Signaling Core provides PIs in our Research Base with construct generation and related services for in vitro experiments, including high-throughput analysis of odorant and taste receptors, and in vivo experiments, including constructs for transgenics and conditional knockouts of odorant and taste receptor genes. The Core also provides advice and training in these areas to Research Base PIs at Monell, Monell faculty, and their staff. The Core is designed to encourage non-molecular biologists to adapt a variety of molecular techniques for their chemosensory signaling projects. Overall oversight of Monell's P30 Core Center is by Dr. Robert Margolskee, Associate Director of Monell and PI of Monell's P30 Center. He coordinates the activities of Monell's P30 Center and will ensure that the new Chemosensory Receptor Signaling Core is integrated with the existing three Research Cores to provide efficient services and training to the researchers in Monell's Research Base. The expertise and technical capabilities provided by the new Chemosensory Receptor Signaling Core are uniquely well suited to Monell's faculty and the PIs of Monell's Research Base, with their focus on the chemical senses. The new Core, through training and services of users will provide new capabilities and enhance productivity of Monell's researchers. Together these four Research Cores will enhance Monell's research in the chemical senses and further the mission of the NIDCD.

Public Health Relevance

The new Chemosensory Receptor Signaling Core will complement the three existing Research Cores of the P30 Core Center at the Monell Chemical Senses Center. The Signaling Core, led by experts in high throughput screening of odorant receptors in vitro, and in manipulation of chemosensory signaling genes in vivo, will enhance the capabilities and productivity of Monell's Research Base in the Chemical Senses.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
3P30DC011735-02S1
Application #
8479478
Study Section
Special Emphasis Panel (ZDC1-SRB-K (11))
Program Officer
Platt, Christopher
Project Start
2011-07-05
Project End
2016-06-30
Budget Start
2013-04-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$148,874
Indirect Cost
$34,274
Name
Monell Chemical Senses Center
Department
Type
DUNS #
088812565
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Adappa, Nithin D; Farquhar, Douglas; Palmer, James N et al. (2016) TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6:25-33
Dibattista, Michele; Reisert, Johannes (2016) The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons. J Neurosci 36:2995-3006
Bachmanov, Alexander A; Bosak, Natalia P; Glendinning, John I et al. (2016) Genetics of Amino Acid Taste and Appetite. Adv Nutr 7:806S-22S
Bobowski, Nuala; Reed, Danielle R; Mennella, Julie A (2016) Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults. Sci Rep 6:39135
Yee, Karen K; Craven, Brent A; Wysocki, Charles J et al. (2016) Comparative Morphology and Histology of the Nasal Fossa in Four Mammals: Gray Squirrel, Bobcat, Coyote, and White-Tailed Deer. Anat Rec (Hoboken) 299:840-52
Poole, Rachel L; Aleman, Tiffany R; Ellis, Hillary T et al. (2016) Maltodextrin Acceptance and Preference in Eight Mouse Strains. Chem Senses 41:45-52
Sukumaran, Sunil K; Yee, Karen K; Iwata, Shusuke et al. (2016) Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc Natl Acad Sci U S A 113:6035-40
Lewandowski, Brian C; Sukumaran, Sunil K; Margolskee, Robert F et al. (2016) Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms. J Neurosci 36:1942-53
Pietra, Gianluca; Dibattista, Michele; Menini, Anna et al. (2016) The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. J Gen Physiol 148:293-311
Prokop-Prigge, Katharine A; Greene, Kathryn; Varallo, Lauren et al. (2016) The Effect of Ethnicity on Human Axillary Odorant Production. J Chem Ecol 42:33-9

Showing the most recent 10 out of 66 publications