One of the unique characteristics of the Monell Center is that researchers use multidisciplinary approaches to address scientific questions regarding taste, smell, nutrition, and their relationship to human health and well-being. The primary expertise of Monell investigators ranges from analytical chemistry and chemical ecology (Drs. Preti and Kimball) to biochemistry and biophysics (Drs. Brand and Margolskee), molecular and cellular biology (Drs. Margolskee, Huang, and Wang), genetics and neuroscience (Drs. Tordoff, Bachmanov, Beauchamp, Reed. Yamazki, Reisert, Gelperin, and Lowe), endocrinology and physiology (Drs. Margolskee, Teff, Friedman, Wysocki, and Zhao), psychophysics and behavioral science (Drs. Mennella, Dalton, Breslin, Lundstrom, Pelchat, and Wise), and clinical research (Drs. Cowart and Teff). Regardless of their primary technical expertise, a number of these laboratories have found it very useful to incorporate histology and cellular localization methods into their research programs (e.g.. Fig. 1)[1]. However, other Center laboratories are less familiar with the techniques and/or equipment involved in anatomical/histological studies. For instance, geneticists such as Drs. Reed and Bachmanov had identified candidate genes for taste receptors that detect the bitter-tasting compound phenylthiocarbamide and sweet-tasting compounds, respectively[2,3]. They needed to determine, first, whether these genes were expressed in the peripheral taste organs, and then, in which types of taste bud cells. These researchers could use reverse-transcripfion PCR with RNA extracted from taste tissue to determine if these candidate gene products are preferentially expressed in taste buds. However, to determine which type of taste bud cells express these genes, in situ hybridization and immunohistochemistry are mostly commonly used on taste fissures. This Core will provide a common resource and reservoir of experience in chemosensory anatomical analysis and state-of-the-art visualization techniques that would be inefficient to replicate in each individual laboratory. Thus, the availability of Core services would extend the capabilities of the participating laboratories beyond each laboratory's capabilities.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1-SRB-Q)
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Monell Chemical Senses Center
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Adappa, Nithin D; Farquhar, Douglas; Palmer, James N et al. (2016) TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. Int Forum Allergy Rhinol 6:25-33
Dibattista, Michele; Reisert, Johannes (2016) The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons. J Neurosci 36:2995-3006
Bachmanov, Alexander A; Bosak, Natalia P; Glendinning, John I et al. (2016) Genetics of Amino Acid Taste and Appetite. Adv Nutr 7:806S-22S
Bobowski, Nuala; Reed, Danielle R; Mennella, Julie A (2016) Variation in the TAS2R31 bitter taste receptor gene relates to liking for the nonnutritive sweetener Acesulfame-K among children and adults. Sci Rep 6:39135
Yee, Karen K; Craven, Brent A; Wysocki, Charles J et al. (2016) Comparative Morphology and Histology of the Nasal Fossa in Four Mammals: Gray Squirrel, Bobcat, Coyote, and White-Tailed Deer. Anat Rec (Hoboken) 299:840-52
Poole, Rachel L; Aleman, Tiffany R; Ellis, Hillary T et al. (2016) Maltodextrin Acceptance and Preference in Eight Mouse Strains. Chem Senses 41:45-52
Sukumaran, Sunil K; Yee, Karen K; Iwata, Shusuke et al. (2016) Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides. Proc Natl Acad Sci U S A 113:6035-40
Lewandowski, Brian C; Sukumaran, Sunil K; Margolskee, Robert F et al. (2016) Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms. J Neurosci 36:1942-53
Pietra, Gianluca; Dibattista, Michele; Menini, Anna et al. (2016) The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. J Gen Physiol 148:293-311
Prokop-Prigge, Katharine A; Greene, Kathryn; Varallo, Lauren et al. (2016) The Effect of Ethnicity on Human Axillary Odorant Production. J Chem Ecol 42:33-9

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