The Human Studies Core has been a component of the Diabetes Research Center since 1974, reflecting the historically strong focus ofthe University of Washington on clinical research. The Core's mission is to provide affiliate investigators with multiple resources to support the conduct of human research. To achieve this mission, the Human Studies Core has the following goals: (1) Perform metabolic phenotyping studies consisting of clamps with isotopic tracers to determine site-specific rates of glucose kinetics, hyperglycemic clamps to assess beta-cell function, and oral and intravenous glucose tolerance tests;(2) Obtain blood samples and adipose tissue from identified subjects;(3) Model data from mixed meal, intravenous and oral glucose tolerance tests to estimate parameters of interest pertaining to beta-cell function, insulin sensitivity and glucose disposal;(4) Utilize existing state-of-the-art electronic medical record and other clinical resources to identify potential subjects for clinical and epidemiological research in diabetes, obesity and related disorders;and (5) Assist with and train in the design and conduct of clinical research including statistical analysis. Many of the services offered by the Human Studies Core are unique in the local research community and, if not for the existence of the Diabetes Research Center, would be unavailable to investigators. By leveraging with other groups, the Center offers services to its affiliates that complement those available through the UW Nutrition Obesity Research Center, the Institute of Translational Health Sciences (the CTSA), the Group Health Research Institute, the VA Epidemiologic Research and Information Center, and the Washington Phenotyped Biospecimen Resource. In this manner, the Human Studies Core supports the conduct of human research in diabetes, obesity and related conditions.

Public Health Relevance

The Human Studies Core provides specialized technical resources and expertise to enhance the efficiency, productivity and multidisciplinary nature of clinical research performed by Diabetes Research Centeraffiliated investigators.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S (O2))
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University of Washington
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Guo, Rui; Hua, Yinan; Ren, Jun et al. (2018) Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity. Cell Death Dis 9:692
van Zuydam, Natalie R; Ahlqvist, Emma; Sandholm, Niina et al. (2018) A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes 67:1414-1427
Tanaka, Shigeru; Pfleger, Christian; Lai, Jen-Feng et al. (2018) KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep 23:796-807
Houston, Denise K; Neiberg, Rebecca H; Miller, Michael E et al. (2018) Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study. J Gerontol A Biol Sci Med Sci 73:1552-1559
Roe, Nathan D; Handzlik, Michal K; Li, Tao et al. (2018) The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function. Sci Rep 8:4983
Chepurny, Oleg G; Bonaccorso, Ron L; Leech, Colin A et al. (2018) Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors. Sci Rep 8:3749
Hull, Rebecca L; Gibson, Ronald L; McNamara, Sharon et al. (2018) Islet Interleukin-1? Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to ?-Cell Failure. Diabetes Care 41:823-830
Koletzko, Sibylle; Lee, Hye-Seung; Beyerlein, Andreas et al. (2018) Cesarean Section on the Risk of Celiac Disease in the Offspring: The Teddy Study. J Pediatr Gastroenterol Nutr 66:417-424
Erickson, Michelle A; Banks, William A (2018) Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions. Pharmacol Rev 70:278-314
Auerbach, Brandon J; Dibey, Sepideh; Vallila-Buchman, Petra et al. (2018) Review of 100% Fruit Juice and Chronic Health Conditions: Implications for Sugar-Sweetened Beverage Policy. Adv Nutr 9:78-85

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