The Pilot and Feasibility (P&F) Program of the Diabetes Research Center at the University of Washington promotes the development of new and innovative research directed at basic, clinical and translational aspects of diabetes. The specific objectives of the Program are to: (1) Provide initial research support for junior faculty who have not yet had independent peer-reviewed NIH funding;(2) Provide pilot funding for established faculty entering the field of diabetes research for the first time;(3) Support pilot projects by established diabetes investigators proposing to pursue a novel direction in their diabetes related research; and (4) Foster mentorqd training in research related to diabetes by offering postdoctoral and graduate fellowships. The P&F Program annually awards $200,000 ofthe Center's NIDDK direct funds (a minimum of 20%) for P&F research projects. In addition, funds provided by the University are used to support new investigator research, training of postdoctoral fellows and graduate students, and service grants for junior investigators to use the Center's resources. Applications are peer-reviewed by external and internal reviewers and the Center's Executive Committee, with awards being made based on scientific merit and qualifications ofthe applicant, including the potential for subsequent external peer-reiviewed funding. During the last decade (two funding cycles), NIDDK funds to the Diabetes Research Center at the University of Washington supported 33 P&F awards, the majority of which were awarded to junior faculty. Of these P&Ffunded investigators, 27 remain active in research related to diabetes, obesity and related disorders (82% success). Ofthe six that are no longer doing diabetes-related research, four are still in academic medicine doing research. Thus, the P&F Program continues to be a highly successful component of the Diabetes Research Center that utilizes funds provided by NIDDK and the University of Washington to support new and innovative research in the area of diabetes, obesity and related disorders, and in this manner also fosters the career development of junior investigators.

Public Health Relevance

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK017047-37
Application #
8441180
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2013-03-13
Budget End
2013-11-30
Support Year
37
Fiscal Year
2013
Total Cost
$327,063
Indirect Cost
$138,463
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Bornfeldt, Karin E (2014) 2013 Russell Ross memorial lecture in vascular biology: cellular and molecular mechanisms of diabetes mellitus-accelerated atherosclerosis. Arterioscler Thromb Vasc Biol 34:705-14
Nishizawa, Tomohiro; Kanter, Jenny E; Kramer, Farah et al. (2014) Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis. Cell Rep 7:356-65
Baskin, Denis G; Hewitt, Stephen M (2014) Improving the state of the science of immunohistochemistry: the Histochemical Society's standards of practice. J Histochem Cytochem 62:691-2
Ho, Jacqueline M; Anekonda, Vishwanath T; Thompson, Benjamin W et al. (2014) Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology 155:2845-57
Look AHEAD Research Group (2014) Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study. Obesity (Silver Spring) 22:5-13
Orozco, S; Yatim, N; Werner, M R et al. (2014) RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis. Cell Death Differ 21:1511-21
Durinovic-Belló, Ivana; Gersuk, Vivian H; Ni, Chester et al. (2014) Avidity-dependent programming of autoreactive T cells in T1D. PLoS One 9:e98074
Martins-Mendes, Daniela; Monteiro-Soares, Matilde; Boyko, Edward John et al. (2014) The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk. J Diabetes Complications 28:632-8
Kratz, Mario; Marcovina, Santica; Nelson, James E et al. (2014) Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not ?-cell function in humans. Am J Clin Nutr 99:1385-96
Duffield, Jeremy S (2014) Cellular and molecular mechanisms in kidney fibrosis. J Clin Invest 124:2299-306

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