The Pilot and Feasibility (P&F) Program of the Diabetes Research Center at the University of Washington promotes the development of new and innovative research directed at basic, clinical and translational aspects of diabetes. The specific objectives of the Program are to: (1) Provide initial research support for junior faculty who have not yet had independent peer-reviewed NIH funding;(2) Provide pilot funding for established faculty entering the field of diabetes research for the first time;(3) Support pilot projects by established diabetes investigators proposing to pursue a novel direction in their diabetes related research; and (4) Foster mentorqd training in research related to diabetes by offering postdoctoral and graduate fellowships. The P&F Program annually awards $200,000 ofthe Center's NIDDK direct funds (a minimum of 20%) for P&F research projects. In addition, funds provided by the University are used to support new investigator research, training of postdoctoral fellows and graduate students, and service grants for junior investigators to use the Center's resources. Applications are peer-reviewed by external and internal reviewers and the Center's Executive Committee, with awards being made based on scientific merit and qualifications ofthe applicant, including the potential for subsequent external peer-reiviewed funding. During the last decade (two funding cycles), NIDDK funds to the Diabetes Research Center at the University of Washington supported 33 P&F awards, the majority of which were awarded to junior faculty. Of these P&Ffunded investigators, 27 remain active in research related to diabetes, obesity and related disorders (82% success). Ofthe six that are no longer doing diabetes-related research, four are still in academic medicine doing research. Thus, the P&F Program continues to be a highly successful component of the Diabetes Research Center that utilizes funds provided by NIDDK and the University of Washington to support new and innovative research in the area of diabetes, obesity and related disorders, and in this manner also fosters the career development of junior investigators.

Public Health Relevance

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Washington
United States
Zip Code
Ikizler, Halil O; Zelnick, Leila; Ruzinski, John et al. (2016) Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease. J Ren Nutr 26:93-102
Tang, Chongren; Houston, Barbara A; Storey, Carl et al. (2016) Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages. J Lipid Res 57:848-57
Ronsein, Graziella E; Hutchins, Patrick M; Isquith, Daniel et al. (2016) Niacin Therapy Increases High-Density Lipoprotein Particles and Total Cholesterol Efflux Capacity But Not ABCA1-Specific Cholesterol Efflux in Statin-Treated Subjects. Arterioscler Thromb Vasc Biol 36:404-11
Kanter, Jenny E; Bornfeldt, Karin E (2016) Impact of Diabetes Mellitus. Arterioscler Thromb Vasc Biol 36:1049-53
Shimizu-Albergine, Masami; Van Yserloo, Brian; Golkowski, Martin G et al. (2016) SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP. Proc Natl Acad Sci U S A 113:E5685-93
Neal, Adam S; Rountree, Austin M; Radtke, Jared R et al. (2016) A method for high-throughput functional imaging of single cells within heterogeneous cell preparations. Sci Rep 6:39319
Rountree, Austin; Karkamkar, Amit; Khalil, Gamal et al. (2016) BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment. Heliyon 2:e00210
Aroda, Vanita R; Edelstein, Sharon L; Goldberg, Ronald B et al. (2016) Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab 101:1754-61
Bornfeldt, Karin E (2016) Does Elevated Glucose Promote Atherosclerosis? Pros and Cons. Circ Res 119:190-3
Willard, Joshua R; Barrow, Breanne M; Zraika, Sakeneh (2016) Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels. Diabetologia :

Showing the most recent 10 out of 1030 publications