The Diabetes Research Center at the University of Washington has existed for over four decades and is part of the national program supported by NIDDK. It acts as the focal point and umbrella for diabetes research in the Greater Seattle area with the goal of promoting an environment of collaborative research on diabetes, obesity and related disorders by (1) Providing support to affiliate investigators through its biomedical research cores; (2) Conducting a pilot and feasibility program that provides grant support for new investigators in diabetes research and to established investigators in other disciplines; (3) Sponsoring an interactive enrichment program comprising lectures, retreats and symposia to inform the community of the latest developments in the area; (4) Ensuring the development of young investigators by providing postdoctoral and graduate student fellowships for salary support and training in its biomedical research cores; and (5) Developing new research methods and technologies based on the evolving needs of its investigators. To accomplish this goal, the Center is organized around five biomedical research cores (Cell Function Analysis Core, Cellular and Molecular Imaging Core, Human Studies Core, Quantitative and Functional Proteomics Core, and Vector and Transgenic Mouse Core) and an Administrative Core that also manages the Pilot and Feasibility Program and the Enrichment Program. Along with the commitment of the University of Washington and other Seattle institutions of research space and additional financial support, the Diabetes Research Center is a dynamic and constantly evolving center that supports 99 Seattle-based affiliate investigators who are making important scientific contributions in the areas of (1) Pathophysiology, prevention and treatment of type 2 diabetes; (2) Central regulation of body weight and glucose metabolism; (3) Complications of diabetes; (4) Etiology, pathogenesis and treatment of type 1 diabetes; and (5) Clinical trials and large-scale epidemiologic studies.

Public Health Relevance

The Diabetes Research Center at the University of Washington has a long-standing tradition and record of facilitating scientific investigation aimed at informing on how best to treat and prevent diabetes. Through its biomedical research cores, Pilot and Feasibility Program as well as its Enrichment Program, it will continue to support over 100 scientists in the Greater Seattle area and beyond who are pursuing basic, translation and clinical investigation in diabetes and related disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK017047-42
Application #
9440150
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
Project Start
2018-02-10
Project End
2022-11-30
Budget Start
2018-02-10
Budget End
2018-11-30
Support Year
42
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Sosenko, Jay M; Geyer, Susan; Skyler, Jay S et al. (2018) The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1. Pediatr Diabetes 19:403-409
Smith, Laura B; Liu, Xiang; Johnson, Suzanne Bennett et al. (2018) Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful? Pediatr Diabetes 19:1025-1033
Kang, Inkyung; Chang, Mary Y; Wight, Thomas N et al. (2018) Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection. J Histochem Cytochem 66:241-259
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Banks, W A; Farr, S A; Salameh, T S et al. (2018) Triglycerides cross the blood-brain barrier and induce central leptin and insulin receptor resistance. Int J Obes (Lond) 42:391-397
Bingley, Polly J; Wherrett, Diane K; Shultz, Ann et al. (2018) Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes. Diabetes Care 41:653-661
RISE Consortium (2018) Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp. Diabetes Care 41:1696-1706
Olivo, Robert E; Davenport, Clemontina A; Diamantidis, Clarissa J et al. (2018) Obesity and synergistic risk factors for chronic kidney disease in African American adults: the Jackson Heart Study. Nephrol Dial Transplant 33:992-1001
Uusitalo, Ulla; Lee, Hye-Seung; Andrén Aronsson, Carin et al. (2018) Early Infant Diet and Islet Autoimmunity in the TEDDY Study. Diabetes Care 41:522-530

Showing the most recent 10 out of 1296 publications