Abstract

This renewal application requests 5 year support for a DERC grant to continue a broad and intensive research program that is now in its 13th year and involving close to 100 scientists who investigate Diabetes Mellitus and related metabolic and endocrine disorders. As in the past, five scientific cores are proposed. Yet, three of those are new or restructured to respond to modern trends of biochemical research and changing needs of DERC investigators. These cores are: 1) An Antibody Production Core; 2) An Electron Microscopy/Morphology Core; 3) A Pancreatic Islet Cell Core; 4) A Protein and Nucleic Acid Chemistry Core; and 5) A Radioimmunoassay Core. These scientific cores will considerably enhance the productivity and interdisciplinary collaboration of Center investigators and will allow them to apply the most modern approaches of biomedical research which are not available to individual laboratories. The application also requests support for an Administrative Core which will be responsible for an intensive Academic Enrichment and a Visiting Scientist Program and will greatly facilitate the interdisciplinary interaction of Center investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK019525-19
Application #
2137342
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1977-03-01
Project End
1997-02-28
Budget Start
1995-03-01
Budget End
1996-02-29
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Kim, Yong Hoon; Marhon, Sajid A; Zhang, Yuxiang et al. (2018) Rev-erb? dynamically modulates chromatin looping to control circadian gene transcription. Science 359:1274-1277
Mowel, Walter K; Kotzin, Jonathan J; McCright, Sam J et al. (2018) Control of Immune Cell Homeostasis and Function by lncRNAs. Trends Immunol 39:55-69
Rickels, Michael R; Peleckis, Amy J; Dalton-Bakes, Cornelia et al. (2018) Continuous Glucose Monitoring for Hypoglycemia Avoidance and Glucose Counterregulation in Long-Standing Type 1 Diabetes. J Clin Endocrinol Metab 103:105-114
Guan, Dongyin; Xiong, Ying; Borck, Patricia C et al. (2018) Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell 174:831-842.e12
Jang, Cholsoon; Chen, Li; Rabinowitz, Joshua D (2018) Metabolomics and Isotope Tracing. Cell 173:822-837
Shoshkes-Carmel, Michal; Wang, Yue J; Wangensteen, Kirk J et al. (2018) Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature 557:242-246
Ibrahim, Fadia; Maragkakis, Manolis; Alexiou, Panagiotis et al. (2018) Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis. Nat Struct Mol Biol 25:302-310
Cooney, Laura G; Milman, Lauren W; Hantsoo, Liisa et al. (2018) Cognitive-behavioral therapy improves weight loss and quality of life in women with polycystic ovary syndrome: a pilot randomized clinical trial. Fertil Steril 110:161-171.e1
Condon, David E; Tran, Phu V; Lien, Yu-Chin et al. (2018) Defiant: (DMRs: easy, fast, identification and ANnoTation) identifies differentially Methylated regions from iron-deficient rat hippocampus. BMC Bioinformatics 19:31
Correnti, Jason M; Gottshall, Lauren; Lin, Annie et al. (2018) Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells. Sci Rep 8:12923

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