The Viral Vector Core is a critical resource for Penn Diabetes Research Center (DRC) members interested in the use of viral vectors for gene therapy and basic research applications. The Vector core provides adenoviral vectors, adeno-associated viral vectors (AAV) and lentiviral vectors and offers a full range of services including cloning, DNA amplification and characterization, vector design and consultation. The Core is located within one of the premier gene therapy research laboratories in the country and specializes in the production and distribution of novel AAV serotype vectors and pseudotyped lentiviral vectors. The objectives of the DRC Vector Core are as follows: Using state-of-the-art facilities and dedicated professional staff, the Core will: (1) provide DRC Center members with access to advanced vector technologies for use in diabetes and related endocrine disorder applications;(2) work with DRC executive committee members to develop vectors or recombinant viruses specifically for use by DRC members;(3) transition newly created vectors with superior transduction profiles developed in Penn laboratories to the Core for validation and distribution to DRC members;(4) provide consultation to DRC members for vector construction and experimental design and (5) develop a web-based interface to accompany the recently developed Vector Core database to enable DRC members to request services, monitor the status of vector production and access historical data on all vectors produced for their laboratory by the Vector Core. The overall goal of the DRC Vector Core, like that of the larger Penn DRC, is to serve investigators at Penn and surrounding institutions, and aid in the advancement of diabetes-related research toward the goal of prevention, treatment, and cures for this devastating disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-S)
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University of Pennsylvania
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Park, Hyeong-Kyu; Ahima, Rexford S (2015) Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism 64:24-34
Mulvey, Claire K; McNeill, Ann M; Girman, Cynthia J et al. (2014) Differential associations of oral glucose tolerance test-derived measures of insulin sensitivity and pancreatic *-cell function with coronary artery calcification and microalbuminuria in type 2 diabetes. Diabetes Care 37:124-33
Roe, Andrea; Hillman, Jennifer; Butts, Samantha et al. (2014) Decreased cholesterol efflux capacity and atherogenic lipid profile in young women with PCOS. J Clin Endocrinol Metab 99:E841-7
Soleimanpour, Scott A; Gupta, Aditi; Bakay, Marina et al. (2014) The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 157:1577-90
Ferguson, Jane F; Mulvey, Claire K; Patel, Parth N et al. (2014) Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers. Mol Nutr Food Res 58:601-13
Tsai, Yu-Cheng; Cooke, Nancy E; Liebhaber, Stephen A (2014) Tissue specific CTCF occupancy and boundary function at the human growth hormone locus. Nucleic Acids Res 42:4906-21
Prenner, Stuart B; Mulvey, Claire K; Ferguson, Jane F et al. (2014) Very low density lipoprotein cholesterol associates with coronary artery calcification in type 2 diabetes beyond circulating levels of triglycerides. Atherosclerosis 236:244-50
Lee, Dolim; Le Lay, John; Kaestner, Klaus H (2014) The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice. Diabetologia 57:1242-8
Li, Ming; Li, Changhong; Allen, Aron et al. (2014) Glutamate dehydrogenase: structure, allosteric regulation, and role in insulin homeostasis. Neurochem Res 39:433-45
Naidoo, Nirinjini; Davis, James G; Zhu, Jingxu et al. (2014) Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism. Aging Cell 13:131-41

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