Metabolomics Core The goals of the Metabolomics Core are to: 1. Provide consultation and training in metabolomic analysis. 2. Enable access to state-of-the-art instrumentation and services for metabolomic analysis. 3. Provide access to highly skilled personnel to aid in the analysis and interpretation of metabolomic data. 4. Develop and/or implement new technologies for metabolomics analysis beneficial to MDRC investigators. The Core owns, maintains, and operates a panel of MS and other instruments that are used to analyze metabolism and to perform metabolomic analyses. The Core accomplishes its goals by providing access to senior personnel versed in the use of technologies for metabolomic analysis. In addition Core personel provide consultation/guidance/training in the use of metabolomic analysis for MDRC members. The Core performs metabolomic analysis of specific metabolites and/or undirected metabolite analysis, and provides subsidies to reduce the cost of accessing these services for MDRC members, thus enhacing the research programs of all MDRC members (at all affilaited institutions) who have need of these services for their diabetes-related research.

Public Health Relevance

This research is relevant to the public health because it will increase our understanding of the events, at the level of changes metabolites, that underiie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020572-36
Application #
8441325
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$73,318
Indirect Cost
$26,168
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Prasad, Suchitra; Neef, Tobias; Xu, Dan et al. (2018) Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells. J Autoimmun 89:112-124
Mahajan, Anubha (see original citation for additional authors) (2018) Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet 50:559-571
Hussain, Syed Saad; Harris, Megan T; Kreutzberger, Alex J B et al. (2018) Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP. Mol Biol Cell 29:1238-1257
Miller, Alison L; Gearhardt, Ashley N; Fredericks, Emily M et al. (2018) Targeting self-regulation to promote health behaviors in children. Behav Res Ther 101:71-81
Rumora, Amy E; Lentz, Stephen I; Hinder, Lucy M et al. (2018) Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons. FASEB J 32:195-207
Woodworth, Hillary L; Perez-Bonilla, Patricia A; Beekly, Bethany G et al. (2018) Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro 5:
Orozco, Luz D; Farrell, Colin; Hale, Christopher et al. (2018) Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet 27:1830-1846
Muir, Lindsey A; Kiridena, Samadhi; Griffin, Cameron et al. (2018) Frontline Science: Rapid adipose tissue expansion triggers unique proliferation and lipid accumulation profiles in adipose tissue macrophages. J Leukoc Biol 103:615-628
Spencer, Michael S; Kieffer, Edith C; Sinco, Brandy et al. (2018) Outcomes at 18 Months From a Community Health Worker and Peer Leader Diabetes Self-Management Program for Latino Adults. Diabetes Care 41:1414-1422
Sujkowski, Alyson; Wessells, Robert (2018) Using Drosophila to Understand Biochemical and Behavioral Responses to Exercise. Exerc Sport Sci Rev 46:112-120

Showing the most recent 10 out of 1823 publications