Metabolomics Core The goals of the Metabolomics Core are to: 1. Provide consultation and training in metabolomic analysis. 2. Enable access to state-of-the-art instrumentation and services for metabolomic analysis. 3. Provide access to highly skilled personnel to aid in the analysis and interpretation of metabolomic data. 4. Develop and/or implement new technologies for metabolomics analysis beneficial to MDRC investigators. The Core owns, maintains, and operates a panel of MS and other instruments that are used to analyze metabolism and to perform metabolomic analyses. The Core accomplishes its goals by providing access to senior personnel versed in the use of technologies for metabolomic analysis. In addition Core personel provide consultation/guidance/training in the use of metabolomic analysis for MDRC members. The Core performs metabolomic analysis of specific metabolites and/or undirected metabolite analysis, and provides subsidies to reduce the cost of accessing these services for MDRC members, thus enhacing the research programs of all MDRC members (at all affilaited institutions) who have need of these services for their diabetes-related research.

Public Health Relevance

This research is relevant to the public health because it will increase our understanding of the events, at the level of changes metabolites, that underiie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020572-36
Application #
8441325
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$73,318
Indirect Cost
$26,168
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zick, Suzanna M; Turgeon, D Kim; Ren, Jianwei et al. (2015) Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer. Mol Carcinog 54:908-15
Krebs, Christopher J; Zhang, Deqiang; Yin, Lei et al. (2014) The KRAB zinc finger protein RSL1 modulates sex-biased gene expression in liver and adipose tissue to maintain metabolic homeostasis. Mol Cell Biol 34:221-32
Simon, Becky R; Learman, Brian S; Parlee, Sebastian D et al. (2014) Sweet taste receptor deficient mice have decreased adiposity and increased bone mass. PLoS One 9:e86454
Vassas, Thomas J; Burghardt, Kyle J; Ellingrod, Vicki L (2014) Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics. Pharmacogenomics 15:61-7
Cawthorn, William P; Scheller, Erica L; Learman, Brian S et al. (2014) Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab 20:368-75
Rothberg, Amy E; McEwen, Laura N; Kraftson, Andrew T et al. (2014) The impact of weight loss on health-related quality-of-life: implications for cost-effectiveness analyses. Qual Life Res 23:1371-6
Liu, Tianju; Yu, Hongfeng; Ullenbruch, Matthew et al. (2014) The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis. PLoS One 9:e88362
Arthur, Anna E; Peterson, Karen E; Shen, Jincheng et al. (2014) Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma. Cancer 120:2704-12
Zhang, Wenliang; Mottillo, Emilio P; Zhao, Jiawei et al. (2014) Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem 289:32178-85
Kim, Boklye; Srinivasan, Ashok; Sabb, Brian et al. (2014) Diffusion tensor imaging of the sural nerve in normal controls. Clin Imaging 38:648-54

Showing the most recent 10 out of 62 publications