The Clinical Core ofthe Michigan Diabetes Research Center (MDRC) provides expertise and services to support basic biomedical research and research that focuses on the translation of basic science findings into potential therapeutics and their testing in eariy phase clinical trials (type 1 translational research).
The Specific Aims of the Clinical Core are: Maintain and continuously update a Diabetes Research Registry to facilitate the recruitment of diabetic subjects into clinical studies Support a Chemistry Laboratory to provide expertise and state-of-the-art analytical services to MDRC investigators Provide both routine and non-routine biostatistical services to assist MDRC investigators in experimental design, data management, and data analysis. The proposed user base for the Clinical Core are investigators engaged in basic biomedical and type 1 translational research focused on prediabetes, the pathogenesis and prevention of diabetes, diabetes treatments, and the prevention and control of diabetic complications including retinopathy, nephropathy, neuropathy and cardiovascular disease. The objective of the Clinical Core is to provide expertise and state-of-the-art shared resources to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and type 1 translational research in diabetes.

Public Health Relevance

The Clinical Core ofthe Michigan Diabetes Research Center (MDRC) provides expertise and services to support basic biomedical research and research that focuses on the translation of basic science findings into potential therapeutics and their testing in eariy phase clinical trials (type 1 translational research). The Specific Aims of the Clinical Core are: Maintain and continuously update a Diabetes Research Registry to facilitate the recruitment of diabetic subjects into clinical studies Support a Chemistry Laboratory to provide expertise and state-of-the-art analytical services to MDRC investigators Provide both routine and non-routine biostatistical services to assist MDRC investigators in experimental design, data management, and data analysis. The proposed user base for the Clinical Core are investigators engaged in basic biomedical and type 1 translational research focused on prediabetes, the pathogenesis and prevention of diabetes, diabetes treatments, and the prevention and control of diabetic complications including retinopathy, nephropathy, neuropathy and cardiovascular disease. The objective of the Clinical Core is to provide expertise and state-of-the-art shared resources to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and type 1 translational research in diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020572-36
Application #
8441328
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$147,591
Indirect Cost
$52,677
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Adams, Jessica M; Pei, Hongjuan; Sandoval, Darleen A et al. (2018) Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes 67:1538-1548
Fernandez, Carmen; DeJesus, Jasmine M; Miller, Alison L et al. (2018) Selective eating behaviors in children: An observational validation of parental report measures. Appetite 127:163-170
Zhang, Sherry; Lu, Chunxia; Das, Arun K et al. (2018) Abrogation of GH action in Kupffer cells results in increased hepatic CD36 expression and exaggerated nonalcoholic fatty liver disease. Growth Horm IGF Res 42-43:74-79
Mishra, Manish; Duraisamy, Arul J; Kowluru, Renu A (2018) Sirt1: A Guardian of the Development of Diabetic Retinopathy. Diabetes 67:745-754
Sas, Kelli M; Lin, Jiahe; Rajendiran, Thekkelnaycke M et al. (2018) Shared and distinct lipid-lipid interactions in plasma and affected tissues in a diabetic mouse model. J Lipid Res 59:173-183
Rios, Peter D; Skoumal, Michael; Liu, Jeffrey et al. (2018) Evaluation of encapsulating and microporous nondegradable hydrogel scaffold designs on islet engraftment in rodent models of diabetes. Biotechnol Bioeng 115:2356-2364
Zhang, Peng; Kuang, Henry; He, Yanlin et al. (2018) NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight 3:
Rosenstock, Julio; Perkovic, Vlado; Alexander, John H et al. (2018) Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardi Cardiovasc Diabetol 17:39
Kady, Nermin M; Liu, Xuwen; Lydic, Todd A et al. (2018) ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. Diabetes 67:769-781
Jaiswal, Mamta; Divers, Jasmin; Urbina, Elaine M et al. (2018) Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. Pediatr Diabetes 19:680-689

Showing the most recent 10 out of 1823 publications