The prevalence of diabetes mellitus in the United States is reaching epidemic proportions and accounts for a huge national burden of morbidity, mortality, and health care expenditures. The Michigan Diabetes Research center (MDRC) builds on the 35-year experience of the Michigan Diabetes Research and Training Center (MDRTC) as a key component of the research effort to promote new discoveries and enhance scientific progress through support of cutting-edge basic and clinical research related to the etiology and complications of diabetes. The goal of the MDRC Is to establish, promote, and enhance multidisciplinary and collaborative basic biomedical and clinical research among member investigators studying diabetes, its complications, and related endocrine and metabolic disorders. The missions of the MDRC are to create an environment that supports important and innovative research;raise awareness and Interest In fundamental and clinical diabetes research at affiliated Institutions and beyond;enhance diabetes research education and training opportunities for patients, students, scientists, and clinicians;attract an retain early stage Investigators and Investigators new to diabetes research;provide core services that leverage funding and unique expertise;foster interdisciplinary collaborations, especially In the emerging areas of research, to catalyze new ideas and scientific approaches;and promote the translation of scientific discoveries from bench to bedside to community to Improve public health.

Public Health Relevance

The MDRC promotes and enhances multidisciplinary and collaborative basic and clinical research relevant to diabetes, its complications, and related endocrine and metabolic disorders. This serves to accelerate the pace and improve the efficiency and cost-effectiveness of biomedical and clinical research to prevent, treat, and ultimately cure diabetes and its complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020572-37
Application #
8617160
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2017-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
37
Fiscal Year
2014
Total Cost
$1,275,025
Indirect Cost
$455,073
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zhang, Hongyu; Nair, Viji; Saha, Jharna et al. (2017) Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice. Kidney Int 92:909-921
Ward, Kristen M; Kraal, A Zarina; Flowers, Stephanie A et al. (2017) Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia. Pharmacotherapy 37:1122-1130
Soofi, Abdul; Wolf, Katherine I; Emont, Margo P et al. (2017) The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem 292:9051-9062
Bian, Rachel R; Piatt, Gretchen A; Sen, Ananda et al. (2017) The Effect of Technology-Mediated Diabetes Prevention Interventions on Weight: A Meta-Analysis. J Med Internet Res 19:e76
Lager, Corey J; Esfandiari, Nazanene H; Subauste, Angela R et al. (2017) Roux-En-Y Gastric Bypass Vs. Sleeve Gastrectomy: Balancing the Risks of Surgery with the Benefits of Weight Loss. Obes Surg 27:154-161
Shen, Hong; Sheng, Liang; Xiong, Yi et al. (2017) Thymic NF-?B-inducing kinase regulates CD4+ T cell-elicited liver injury and fibrosis in mice. J Hepatol 67:100-109
Hinder, Lucy M; O'Brien, Phillipe D; Hayes, John M et al. (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10:717-725
Cady, Gillian; Landeryou, Taylor; Garratt, Michael et al. (2017) Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab 6:393-405
Welch, Whitney A; Alexander, Neil B; Swartz, Ann M et al. (2017) Individualized Estimation of Physical Activity in Older Adults with Type 2 Diabetes. Med Sci Sports Exerc 49:2185-2190
O'Brien, Phillipe D; Hinder, Lucy M; Parlee, Sebastian D et al. (2017) Dual CCR2/CCR5 antagonist treatment attenuates adipose inflammation, but not microvascular complications in ob/ob mice. Diabetes Obes Metab 19:1468-1472

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