Metabolomics Core The goals of the Metabolomics Core are to: 1. Provide consultation and training in metabolomic analysis. 2. Enable access to state-of-the-art instrumentation and services for metabolomic analysis. 3. Provide access to highly skilled personnel to aid in the analysis and interpretation of metabolomic data. 4. Develop and/or implement new technologies for metabolomics analysis beneficial to MDRC investigators. The Core owns, maintains, and operates a panel of MS and other instruments that are used to analyze metabolism and to perform metabolomic analyses. The Core accomplishes its goals by providing access to senior personnel versed in the use of technologies for metabolomic analysis. In addition Core personel provide consultation/guidance/training in the use of metabolomic analysis for MDRC members. The Core performs metabolomic analysis of specific metabolites and/or undirected metabolite analysis, and provides subsidies to reduce the cost of accessing these services for MDRC members, thus enhacing the research programs of all MDRC members (at all affilaited institutions) who have need of these services for their diabetes-related research.

Public Health Relevance

This research is relevant to the public health because it will increase our understanding of the events, at the level of changes metabolites, that underiie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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University of Michigan Ann Arbor
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Wong, Jenny-Marie T; Malec, Paige A; Mabrouk, Omar S et al. (2016) Benzoyl chloride derivatization with liquid chromatography-mass spectrometry for targeted metabolomics of neurochemicals in biological samples. J Chromatogr A 1446:78-90
Grinias, James P; Wong, Jenny-Marie T; Kennedy, Robert T (2016) Repeatability of gradient ultrahigh pressure liquid chromatography-tandem mass spectrometry methods in instrument-controlled thermal environments. J Chromatogr A 1461:42-50
Hu, Fang; Knoedler, Joseph R; Denver, Robert J (2016) A Mechanism to Enhance Cellular Responsivity to Hormone Action: Krüppel-Like Factor 9 Promotes Thyroid Hormone Receptor-β Autoinduction During Postembryonic Brain Development. Endocrinology 157:1683-93
Taylor, Veronica G; Bommarito, Paige A; Tesmer, John J G (2016) Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY. J Biol Chem 291:5138-45
Hrycaj, Steven M; Wellik, Deneen M (2016) Hox genes and evolution. F1000Res 5:
Korot, Edward; Comer, Grant; Steffens, Timothy et al. (2016) Algorithm for the Measure of Vitreous Hyperreflective Foci in Optical Coherence Tomographic Scans of Patients With Diabetic Macular Edema. JAMA Ophthalmol 134:15-20
Allen, Susan J; Garcia-Galiano, David; Borges, Beatriz C et al. (2016) Leptin receptor null mice with reexpression of LepR in GnRHR expressing cells display elevated FSH levels but remain in a prepubertal state. Am J Physiol Regul Integr Comp Physiol 310:R1258-66
Airik, Rannar; Schueler, Markus; Airik, Merlin et al. (2016) A FANCD2/FANCI-Associated Nuclease 1-Knockout Model Develops Karyomegalic Interstitial Nephritis. J Am Soc Nephrol 27:3552-3559
Fitzgerald, James T; Funnell, Martha M; Anderson, Robert M et al. (2016) Validation of the Revised Brief Diabetes Knowledge Test (DKT2). Diabetes Educ 42:178-87
Cras-Méneur, Corentin; Elghazi, Lynda; Fort, Patrice et al. (2016) Noninvasive in vivo imaging of embryonic β-cell development in the anterior chamber of the eye. Islets 8:35-47

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