Metabolomics Core The goals of the Metabolomics Core are to: 1. Provide consultation and training in metabolomic analysis. 2. Enable access to state-of-the-art instrumentation and services for metabolomic analysis. 3. Provide access to highly skilled personnel to aid in the analysis and interpretation of metabolomic data. 4. Develop and/or implement new technologies for metabolomics analysis beneficial to MDRC investigators. The Core owns, maintains, and operates a panel of MS and other instruments that are used to analyze metabolism and to perform metabolomic analyses. The Core accomplishes its goals by providing access to senior personnel versed in the use of technologies for metabolomic analysis. In addition Core personel provide consultation/guidance/training in the use of metabolomic analysis for MDRC members. The Core performs metabolomic analysis of specific metabolites and/or undirected metabolite analysis, and provides subsidies to reduce the cost of accessing these services for MDRC members, thus enhacing the research programs of all MDRC members (at all affilaited institutions) who have need of these services for their diabetes-related research.

Public Health Relevance

This research is relevant to the public health because it will increase our understanding of the events, at the level of changes metabolites, that underiie the development of diabetes and its complications, and hence will facilitate the development of improved diagnostic, prevention and treatment strategies

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020572-37
Application #
8617163
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
37
Fiscal Year
2014
Total Cost
$69,975
Indirect Cost
$24,975
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Zhang, Hongyu; Nair, Viji; Saha, Jharna et al. (2017) Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice. Kidney Int 92:909-921
Ward, Kristen M; Kraal, A Zarina; Flowers, Stephanie A et al. (2017) Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia. Pharmacotherapy 37:1122-1130
Soofi, Abdul; Wolf, Katherine I; Emont, Margo P et al. (2017) The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem 292:9051-9062
Bian, Rachel R; Piatt, Gretchen A; Sen, Ananda et al. (2017) The Effect of Technology-Mediated Diabetes Prevention Interventions on Weight: A Meta-Analysis. J Med Internet Res 19:e76
Lager, Corey J; Esfandiari, Nazanene H; Subauste, Angela R et al. (2017) Roux-En-Y Gastric Bypass Vs. Sleeve Gastrectomy: Balancing the Risks of Surgery with the Benefits of Weight Loss. Obes Surg 27:154-161
Shen, Hong; Sheng, Liang; Xiong, Yi et al. (2017) Thymic NF-?B-inducing kinase regulates CD4+ T cell-elicited liver injury and fibrosis in mice. J Hepatol 67:100-109
Hinder, Lucy M; O'Brien, Phillipe D; Hayes, John M et al. (2017) Dietary reversal of neuropathy in a murine model of prediabetes and metabolic syndrome. Dis Model Mech 10:717-725
Cady, Gillian; Landeryou, Taylor; Garratt, Michael et al. (2017) Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Mol Metab 6:393-405
Welch, Whitney A; Alexander, Neil B; Swartz, Ann M et al. (2017) Individualized Estimation of Physical Activity in Older Adults with Type 2 Diabetes. Med Sci Sports Exerc 49:2185-2190
O'Brien, Phillipe D; Hinder, Lucy M; Parlee, Sebastian D et al. (2017) Dual CCR2/CCR5 antagonist treatment attenuates adipose inflammation, but not microvascular complications in ob/ob mice. Diabetes Obes Metab 19:1468-1472

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