To serve a wider scientific community, we propose to leverage the successes and experience of the Washington University Diabetes Research Center (WUMS DRC) in a Shared National Resource Component with two distinct aims: 1, To extend our Pilot &Feasibility Program to diabetes investigators at institutions without NIDDK Diabetes Centers, we propose to establish subcontracts with University of Kentucky and University of Utah. These two universities have outstanding research bases in diabetes with a shared strong focus on diabetic cardiovascular complications. Philip Kern and Dale Abel, internationally recognized diabetes researchers with strong records of leadership, will serve as the subcontract Program Directors at Kentucky and Utah respectively. Each subcontract will fund two meritorious Pilot & Feasibility grants per year at each institution, and the program will be well-integrated with the successful Pilot &Feasibility Program at WUMS. 2. To make available the services of the WUMS DRC Immunoassay and Mass Spectrometry Cores to diabetes investigators on a national level, we propose to dedicate resources specifically for work performed in these Cores for diabetes investigators at other institutions. This effort will build on the substantial expertise of these two long-standing, highly functioning cores with track records of service to outside users.
To serve the broader scientific community and advance progress towards better treatments, preventive strategies, and cures for diabetes, the WUMS DRC proposes a Shared National Resource component that will leverage the success of an established pilot grant program and broaden the scope of two long-standing, highly experienced biomedical research cores.
|Gaut, Joseph P; Crimmins, Dan L; Ohlendorf, Matt F et al. (2014) Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem 60:747-57|
|Hsu, Fong-Fu; Kuhlmann, F Matthew; Turk, John et al. (2014) Multiple-stage linear ion-trap with high resolution mass spectrometry towards complete structural characterization of phosphatidylethanolamines containing cyclopropane fatty acyl chain in Leishmania infantum. J Mass Spectrom 49:201-9|
|Vigueira, Patrick A; McCommis, Kyle S; Schweitzer, George G et al. (2014) Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion. Cell Rep 7:2042-53|
|Calderon, Boris; Carrero, Javier A; Unanue, Emil R (2014) The central role of antigen presentation in islets of Langerhans in autoimmune diabetes. Curr Opin Immunol 26:32-40|
|Asombang, Akwi W; Rahman, Rubayat; Ibdah, Jamal A (2014) Gastric cancer in Africa: current management and outcomes. World J Gastroenterol 20:3875-9|
|Fabbrini, Elisa; Serafini, Mauro; Colic Baric, Irena et al. (2014) Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes 63:976-81|
|Schugar, Rebecca C; Moll, Ashley R; André d'Avignon, D et al. (2014) Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling. Mol Metab 3:754-69|
|Yoshino, Jun; Almeda-Valdes, Paloma; Patterson, Bruce W et al. (2014) Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. J Clin Endocrinol Metab 99:E1666-70|
|Napoli, Nicola; Shah, Krupa; Waters, Debra L et al. (2014) Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults. Am J Clin Nutr 100:189-98|
|Aguirre, Lina; Napoli, Nicola; Waters, Debra et al. (2014) Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults. J Clin Endocrinol Metab 99:3290-7|
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