To serve a wider scientific community, we propose to leverage the successes and experience of the Washington University Diabetes Research Center (WUMS DRC) in a Shared National Resource Component with two distinct aims: 1, To extend our Pilot &Feasibility Program to diabetes investigators at institutions without NIDDK Diabetes Centers, we propose to establish subcontracts with University of Kentucky and University of Utah. These two universities have outstanding research bases in diabetes with a shared strong focus on diabetic cardiovascular complications. Philip Kern and Dale Abel, internationally recognized diabetes researchers with strong records of leadership, will serve as the subcontract Program Directors at Kentucky and Utah respectively. Each subcontract will fund two meritorious Pilot & Feasibility grants per year at each institution, and the program will be well-integrated with the successful Pilot &Feasibility Program at WUMS. 2. To make available the services of the WUMS DRC Immunoassay and Mass Spectrometry Cores to diabetes investigators on a national level, we propose to dedicate resources specifically for work performed in these Cores for diabetes investigators at other institutions. This effort will build on the substantial expertise of these two long-standing, highly functioning cores with track records of service to outside users.

Public Health Relevance

To serve the broader scientific community and advance progress towards better treatments, preventive strategies, and cures for diabetes, the WUMS DRC proposes a Shared National Resource component that will leverage the success of an established pilot grant program and broaden the scope of two long-standing, highly experienced biomedical research cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020579-36
Application #
8441808
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$264,186
Indirect Cost
$26,000
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Rusconi, B; Jiang, X; Sidhu, R et al. (2018) Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis. Sci Rep 8:10984
Chen, Yana; McCommis, Kyle S; Ferguson, Daniel et al. (2018) Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid. Endocrinology 159:609-621
Zhang, Yan; Rohatgi, Nidhi; Veis, Deborah J et al. (2018) PGC1? Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation. J Bone Miner Res 33:1114-1125
Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256
Hughes, Jing W; Bao, Yicheng K; Salam, Maamoun et al. (2018) Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease. Diabetes Care :
Zhang, Xiangyu; Evans, Trent D; Jeong, Se-Jin et al. (2018) Classical and alternative roles for autophagy in lipid metabolism. Curr Opin Lipidol 29:203-211
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. J Lipid Res 59:1414-1423
Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:
Mayer, Allyson L; Zhang, Yiming; Feng, Emily H et al. (2018) Enhanced Hepatic PPAR? Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology 159:2110-2126
Weber, Kassandra J; Sauer, Madeline; He, Li et al. (2018) PPAR? Deficiency Suppresses the Release of IL-1? and IL-1? in Macrophages via a Type 1 IFN-Dependent Mechanism. J Immunol 201:2054-2069

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