The Metabolic Physiology Shared Resource (MPSR) provides investigators with a platform for the design, execution, and interpretation of highly specialized procedures for conducting experiments in vivo. The MPSR facilitates research for investigators in the range of species spanning from mouse to humans. Many of the basic tenets of experimental design are species-Independent permitting resources and expertise to be pooled under the common MPSR umbrella. This philosophy alleviates experimental constraints by providing access to a variety of model systems and provides for seamless translation of basic experimental findings to humans. The impact and benefits of the MPSR are greater than the sum of Its constituent parts. The MPSR uses a defined mechanism for the design and optimization of experimental protocols using an established Studio format. The Studio (i) brings together Vanderbilt scientists with specific expertise to review a proposal;(ii) identifies potential limitations on the front-end;and (iii) leads to the most efficient use of resources including animals and human volunteers. The MPSR makes complex In vivo experiments feasible by providing specialized animal surgical (e.g. catheter placement, bariatric surgery) and experimental (e.g. clamps, energy balance) services. Advancements in the present cycle have led to the development of bariatric surgery procedures and expansion of resources for energy balance measurements In animals that parallel procedures used In human studies conducted by the MPSR. The MPSR has also added a human clamp component. The addition of these vital services fills out the scope of services leading to comprehensive analyses of insulin action and energy balance from rodents to large animals to human subjects. MPSR services will channel into analytical, statistical, and bioinformatics services, thereby enhancing the utility of this resource.

Public Health Relevance

The MPSR gives DRTC investigators studying obesity and diabetes access to novel in vivo animal model systems which can be extended to human subjects. Conversely findings in patient populations can be studied in the MPSR at a more basic level in animals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK020593-35
Application #
8469489
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
35
Fiscal Year
2013
Total Cost
$186,259
Indirect Cost
$66,862
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Moore, Mary Courtney; Smith, Marta S; Farmer, Ben et al. (2018) Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day. Diabetes 67:1237-1245
Cooke, Allison L; Morris, Jamie; Melchior, John T et al. (2018) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL. J Lipid Res 59:1244-1255
Moore, Mary Courtney; Kelley, David E; Camacho, Raul C et al. (2018) Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts. Diabetes 67:1173-1181
Funkhouser-Jones, Lisa J; van Opstal, Edward J; Sharma, Ananya et al. (2018) The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia. Curr Biol 28:1692-1702.e6
Hart, Nathaniel J; Aramandla, Radhika; Poffenberger, Gregory et al. (2018) Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI Insight 3:
Uddin, Md Imam; Jayagopal, Ashwath; Wong, Alexis et al. (2018) Real-time imaging of VCAM-1 mRNA in TNF-? activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Nanomedicine 14:63-71
Sui, Lina; Danzl, Nichole; Campbell, Sean R et al. (2018) ?-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells. Diabetes 67:26-35
Beach, Lauren B; Elasy, Tom A; Gonzales, Gilbert (2018) Prevalence of Self-Reported Diabetes by Sexual Orientation: Results from the 2014 Behavioral Risk Factor Surveillance System. LGBT Health 5:121-130
Dutter, Brendan F; Ender, Anna; Sulikowski, Gary A et al. (2018) Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org Biomol Chem 16:5575-5579
Horwitz, Elad; Krogvold, Lars; Zhitomirsky, Sophia et al. (2018) ?-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes. Diabetes 67:2305-2318

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