An Animal Models and Physiology Core has been a unit of the DRTC since 1991. It was initially established to assist investigators in the generation of genetically modified mice. The Core has continued to evolve during the past funding period and now includes Mouse Metabolic Phenotyping as a service. The Animal Model and Physiology Core provides to Center members via access to a wide array of resources, technology, equipment and services for the generation and study of genetically modified mice and other model organisms in diabetes-related research, consultation on experimental design and analysis, repositories (mouse and human ES cells, mouse models), technology development (large-scale analysis of pancreatic islets from mice to man) and opportunities for collaboration. Some services are widely used (e.g. generation of transgenic and knockout mice and metabolic phenotyping) whereas others less so (advice and training in human ES cells). Nonetheless, rather than discontinuing unique or very specialized but rarely used services, we still list them on the DRTC website since future needs of members cannot be predicted and the leadership believes strongly that including them allows members to consider all available technologies in planning their research. Drs. Manami Hara and Anita Chong will continue to serve as Director and Co-Director of this Core. They will also be assisted by Technical Directors for Transgenic/ES Cell Technology (Degenstein) and Mouse Metabolic Phenotyping (Ye). The Core will have an internal advisory panel comprised of investigators using model organisms for diabetes/metabolism-related research: mice (Bass, Bell and Nobrega), zebrafish (Prince), Drosophila (Kreitman) and C. elegans (Ruvinsky). This organization will ensure that Core services are at the forefront of model organism studies and responsive to the needs of DRTC members

Public Health Relevance

The Animal Models Core provides services, advice and hands-on-training for the generation and use of model organisms including mice, Zebrafish, Drosophiia and C elegans in the study of diabetes and metabolism. It facilitates the generation of useful models for studying pancreatic beta cells and the biology and physiology of genes implicated in the development of diabetes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK020595-36
Application #
8446548
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O2))
Project Start
2013-02-01
Project End
2018-01-31
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
36
Fiscal Year
2013
Total Cost
$178,507
Indirect Cost
$65,528
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Bergeron, Valérie; Ghislain, Julien; Vivot, Kevin et al. (2018) Deletion of Protein Kinase D1 in Pancreatic ?-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Diabetes 67:71-77
Chen, Han; Cade, Brian E; Gleason, Kevin J et al. (2018) Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol 58:391-401
Go??b, Karolina; Grose, Randall; Placencia, Veronica et al. (2018) Cell banking for regulatory T cell-based therapy: strategies to overcome the impact of cryopreservation on the Treg viability and phenotype. Oncotarget 9:9728-9740
Xiang, Anny H; Trigo, Enrique; Martinez, Mayra et al. (2018) Impact of Gastric Banding Versus Metformin on ?-Cell Function in Adults With Impaired Glucose Tolerance or Mild Type 2 Diabetes. Diabetes Care 41:2544-2551
Reardon, Catherine A; Lingaraju, Amulya; Schoenfelt, Kelly Q et al. (2018) Obesity and Insulin Resistance Promote Atherosclerosis through an IFN?-Regulated Macrophage Protein Network. Cell Rep 23:3021-3030
Priyadarshini, Medha; Kotlo, Kumar U; Dudeja, Pradeep K et al. (2018) Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology. Compr Physiol 8:1091-1115
Kirkley, Andrew G; Carmean, Christopher M; Ruiz, Daniel et al. (2018) Arsenic exposure induces glucose intolerance and alters global energy metabolism. Am J Physiol Regul Integr Comp Physiol 314:R294-R303
Spires, Denisha; Ilatovskaya, Daria V; Levchenko, Vladislav et al. (2018) Protective role of Trpc6 knockout in the progression of diabetic kidney disease. Am J Physiol Renal Physiol 315:F1091-F1097
Vaicik, Marcella K; Blagajcevic, Alen; Ye, Honggang et al. (2018) The Absence of Laminin ?4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue. Endocrinology 159:356-367
Yamamoto, Soh; Kuramoto, Kenta; Wang, Nan et al. (2018) Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity. Cell Rep 23:3286-3299

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