The Energy Balance Phenotpying Core provides services to the members ofthe NYORC and to other eligible investigators. These services include consultation, assessment of energy intake, energy expenditure, and body composition. The Core is actively engaged in phenotyping mouse and rat models of obesity and is in a unique position to provide the stated services. The development of obesity in animal models is dependent on hyperphagia;exaniples are leptin and leptin receptor deficient rodents. The hyperphagia is dependent on influences from the hypothalamus, as targeted ablation of neuropeptide expression partially corrects this defect in ingestive behavior. Two of the NYORC Cores, Energy Balance Phenotyping and the Molecular Biology/Molecular Genetics Core, have done a series of ontogenetic studies to correlate the onset of hyperphagia with overexpression of a hypothalamic neuropeptide, NPY. The Molecular Biology/Molecular Genetics Core provided the breeders and the genotyping assays to determine gene dosage for leptin receptor mutation which the Energy Balance Phenotyping Core performed measures of caloric intake. These studies provided a temporal relationship between over-expression of an orexigenic peptide and hyperphagia, consistent with the hypothesis that increased activity of NPY neurons is partly responsible for the obesity/diabetes syndrome of leptin and leptin receptor deficiency. This type of collaboration between investigators in the Molecular Biology/Molecular Genetics core and the Energy Balance Phenotyping core are expected to continue and expand over the next 5 years of investigation. The collective experience ofthe Core's staff provides a broad range of expertise in ingestive behavior, metabolic physiology and body composition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK026687-31
Application #
8132717
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Project Start
2011-04-01
Project End
2016-03-31
Budget Start
2011-06-10
Budget End
2012-03-31
Support Year
31
Fiscal Year
2011
Total Cost
$204,301
Indirect Cost
Name
St. Luke's-Roosevelt Institute for Health Sciences
Department
Type
DUNS #
623216371
City
New York
State
NY
Country
United States
Zip Code
10019
Shechter, Ari; Foster, Gary D; Lang, Wei et al. (2017) Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes. J Sleep Res 26:747-755
Hua, Haiqing; Shang, Linshan; Martinez, Hector et al. (2017) iPSC-derived ? cells model diabetes due to glucokinase deficiency. J Clin Invest 127:1115
Wang, Liheng; Sui, Lina; Panigrahi, Sunil K et al. (2017) PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem Cell Reports 8:264-277
Espeland, Mark A; Luchsinger, José A; Baker, Laura D et al. (2017) Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment. Neurology 88:2026-2035
Burke, Luke K; Darwish, Tamana; Cavanaugh, Althea R et al. (2017) mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife 6:
Kim, Catherine; Dabelea, Dana; Kalyani, Rita R et al. (2017) Changes in Visceral Adiposity, Subcutaneous Adiposity, and Sex Hormones in the Diabetes Prevention Program. J Clin Endocrinol Metab 102:3381-3389
Schwartz, Michael W; Seeley, Randy J; Zeltser, Lori M et al. (2017) Obesity Pathogenesis: An Endocrine Society Scientific Statement. Endocr Rev 38:267-296
Mange, François; Praz, Viviane; Migliavacca, Eugenia et al. (2017) Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock. Genome Res 27:973-984
Herman, William H; Pan, Qing; Edelstein, Sharon L et al. (2017) Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care 40:1668-1677
Stano, Sarah; Alam, Fatima; Wu, Louis et al. (2017) Effect of meal size and texture on gastric pouch emptying and glucagon-like peptide 1 after gastric bypass surgery. Surg Obes Relat Dis 13:1975-1983

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