The mission of the Hormone &Metabolite Core is to assist investigators by performing uniform and standardized assays of various plasma metabolites, hormones, adipokines and cytokines in rodent models and human studies related to the regulation of obesity and co-morbidities, energy balance, eating disorders and nutrition related problems. The assay services provided within this Core provide an integrative framework for understanding obesity and associated disorders in glucose and lipid metabolism. In addition, the data obtained directly relate to and integrate with the analyses performed in the Body Composition, Animal Energy Balance Phenotyping, the Adipocyte and the Molecular Genetic Cores ofthe Center. The services provided at the HMC are best based in a Core Laboratory because they require special instrumentation and methodology, which would be difficult or impracticably expensive to establish in the laboratories of the individual investigators who are Members ofthe NYONRC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK026687-32
Application #
8461409
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
32
Fiscal Year
2012
Total Cost
$187,115
Indirect Cost
$39,754
Name
St. Luke's-Roosevelt Institute for Health Sciences
Department
Type
DUNS #
623216371
City
New York
State
NY
Country
United States
Zip Code
10019
Shechter, Ari; Foster, Gary D; Lang, Wei et al. (2017) Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes. J Sleep Res 26:747-755
Hua, Haiqing; Shang, Linshan; Martinez, Hector et al. (2017) iPSC-derived ? cells model diabetes due to glucokinase deficiency. J Clin Invest 127:1115
Wang, Liheng; Sui, Lina; Panigrahi, Sunil K et al. (2017) PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem Cell Reports 8:264-277
Espeland, Mark A; Luchsinger, José A; Baker, Laura D et al. (2017) Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment. Neurology 88:2026-2035
Burke, Luke K; Darwish, Tamana; Cavanaugh, Althea R et al. (2017) mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife 6:
Kim, Catherine; Dabelea, Dana; Kalyani, Rita R et al. (2017) Changes in Visceral Adiposity, Subcutaneous Adiposity, and Sex Hormones in the Diabetes Prevention Program. J Clin Endocrinol Metab 102:3381-3389
Schwartz, Michael W; Seeley, Randy J; Zeltser, Lori M et al. (2017) Obesity Pathogenesis: An Endocrine Society Scientific Statement. Endocr Rev 38:267-296
Mange, François; Praz, Viviane; Migliavacca, Eugenia et al. (2017) Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock. Genome Res 27:973-984
Herman, William H; Pan, Qing; Edelstein, Sharon L et al. (2017) Impact of Lifestyle and Metformin Interventions on the Risk of Progression to Diabetes and Regression to Normal Glucose Regulation in Overweight or Obese People With Impaired Glucose Regulation. Diabetes Care 40:1668-1677
Stano, Sarah; Alam, Fatima; Wu, Louis et al. (2017) Effect of meal size and texture on gastric pouch emptying and glucagon-like peptide 1 after gastric bypass surgery. Surg Obes Relat Dis 13:1975-1983

Showing the most recent 10 out of 773 publications