The Energy Balance Phenotpying Core provides services to the members ofthe NYORC and to other eligible investigators. These services include consultation, assessment of energy intake, energy expenditure, and body composition. The Core is actively engaged in phenotyping mouse and rat models of obesity and is in a unique position to provide the stated services. The development of obesity in animal models is dependent on hyperphagia;exaniples are leptin and leptin receptor deficient rodents. The hyperphagia is dependent on influences from the hypothalamus, as targeted ablation of neuropeptide expression partially corrects this defect in ingestive behavior. Two of the NYORC Cores, Energy Balance Phenotyping and the Molecular Biology/Molecular Genetics Core, have done a series of ontogenetic studies to correlate the onset of hyperphagia with overexpression of a hypothalamic neuropeptide, NPY. The Molecular Biology/Molecular Genetics Core provided the breeders and the genotyping assays to determine gene dosage for leptin receptor mutation which the Energy Balance Phenotyping Core performed measures of caloric intake. These studies provided a temporal relationship between over-expression of an orexigenic peptide and hyperphagia, consistent with the hypothesis that increased activity of NPY neurons is partly responsible for the obesity/diabetes syndrome of leptin and leptin receptor deficiency. This type of collaboration between investigators in the Molecular Biology/Molecular Genetics core and the Energy Balance Phenotyping core are expected to continue and expand over the next 5 years of investigation. The collective experience ofthe Core's staff provides a broad range of expertise in ingestive behavior, metabolic physiology and body composition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK026687-34
Application #
8639524
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
St. Luke's-Roosevelt Institute for Health Sciences
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10019
Grijalva, Ambar; Xu, Xiaoyuan; Ferrante Jr, Anthony W (2016) Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue. Diabetes 65:967-80
Leung, Vivien; Chiu, Ya-Lin; Kotler, Donald P et al. (2016) Effect of Recombinant Human Growth Hormone and Rosiglitazone for HIV-Associated Abdominal Fat Accumulation on Adiponectin and other Markers of Inflammation. HIV Clin Trials 17:55-62
Shechter, Ari (2016) Obstructive sleep apnea and energy balance regulation: A systematic review. Sleep Med Rev :
Chang, Hye Rim; Kim, Hae Jin; Xu, Xiaoyuan et al. (2016) Macrophage and adipocyte IGF1 maintain adipose tissue homeostasis during metabolic stresses. Obesity (Silver Spring) 24:172-83
Ge, Fengxia; Walewski, José L; Torghabeh, Mehyar Hefazi et al. (2016) Facilitated long chain fatty acid uptake by adipocytes remains upregulated relative to BMI for more than a year after major bariatric surgical weight loss. Obesity (Silver Spring) 24:113-22
Wang, Liheng; Egli, Dieter; Leibel, Rudolph L (2016) Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells. Curr Protoc Hum Genet 90:21.5.1-21.5.14
Rosenbaum, Michael; Leibel, Rudolph L (2016) Models of energy homeostasis in response to maintenance of reduced body weight. Obesity (Silver Spring) 24:1620-9
Kotler, Donald P; He, Qing; Engelson, Ellen S et al. (2016) The effect of recombinant human growth hormone with or without rosiglitazone on hepatic fat content in HIV-1-infected individuals: a randomized clinical trial. Antivir Ther 21:107-16
Shechter, Ari (2016) Effects of continuous positive airway pressure on energy balance regulation: a systematic review. Eur Respir J 48:1640-1657
Paley, C; Hull, H; Ji, Y et al. (2016) Body fat differences by self-reported race/ethnicity in healthy term newborns. Pediatr Obes 11:361-8

Showing the most recent 10 out of 623 publications