The Liver Center of the University of California, San Francisco (UCSF) is an interdisciplinary consortium of 82 basic and clinical scientists dedicated to understanding the biology and pathobiology of the liver and the treatment of liver diseases. Research by Center members is categorized under three basic biological themes: (1) Liver Injury and Repair, (2) Progenitor Cells, Growth and Development and (3) Hepatic Physiology and Metabolism. Across all themes, research spans bench to bedside, with approximately half of Center members being directly involved in clinical and translational studies. From 2008-2013 the Center will support three Biomedical Research Cores: (1) Cell Biology, (2) Liver Immunology &Cell Analysis and (3) Pathology. A Clinical Component, which offers biostatistical support to supplement the services offered by the UCSF Clinical and Translational Science Institute, is part of the Administrative Core. Also within the Administrative Core is the Tool &Technology Program;this is a """"""""user-defined"""""""" or """"""""a la carte"""""""" core designed to support member use of core services at UCSF not provided directly by the Center. The goals of the Center are to provide research support, technical training, a venue for new collaborations and an entry point for new members. The Center also fosters scientific exchange through an Enrichment Program that features seminars by local and visiting scientists, quarterly mini-symposia highlighting each research theme, and an annual 1-day symposium with a lively poster session. A vital component of the Center is its Pilot/Feasibility Program, which provides seed money to junior investigators and scientists new to investigative hepatology. This award program, like the cores, is an important recruitment vehicle. The Center continues to expand its support of member science through strategic partnerships with the Gladstone Institutes and affiliations, with other organized research units at UCSF. The funding base of the Center continues to grow, and support from the institution is sustained and strong. Opportunities for basic biologic discovery and the application of basic science to clinical liver disease are numerous;the Center is poised to catalyze achievements in these areas.

Public Health Relevance

The UCSF Liver Center provides a valuable research infrastructure and a scientific home to scientists who study liver biology and disease. The Center's core facilities offer high-quality, liver-focused services;the consortium creates a platform for exchange of ideas. Overall the environment of a Center accelerates scientific discovery and enhances the productivity and fulfillment of its members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK026743-31
Application #
8451695
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O2))
Program Officer
Podskalny, Judith M,
Project Start
1996-12-01
Project End
2018-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
31
Fiscal Year
2013
Total Cost
$1,177,188
Indirect Cost
$427,188
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Lee, Briton; Holt, Edward W; Wong, Robert J et al. (2018) Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. Autoimmunity 51:258-264
Roberts, Daniel E; Kakar, Sanjay; Mehta, Neil et al. (2018) A Point-based Histologic Scoring System for Hepatocellular Carcinoma Can Stratify Risk of Posttransplant Tumor Recurrence. Am J Surg Pathol 42:855-865
Sarkar, Monika; Bramham, Kate; Moritz, Michael J et al. (2018) Reproductive health in women following abdominal organ transplant. Am J Transplant 18:1068-1076
Perito, Emily R; Phelps, Andrew; Vase, Tabitha et al. (2018) Subclinical Atherosclerosis in Pediatric Liver Transplant Recipients: Carotid and Aorta Intima-Media Thickness and Their Predictors. J Pediatr 193:119-127.e1
Schaub, Johanna R; Huppert, Kari A; Kurial, Simone N T et al. (2018) De novo formation of the biliary system by TGF?-mediated hepatocyte transdifferentiation. Nature 557:247-251
Wang, Jingxiao; Dong, Mingjie; Xu, Zhong et al. (2018) Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene 37:3229-3242
Kotwani, Prashant; Saxena, Varun; Dodge, Jennifer L et al. (2018) History of Marijuana Use Does Not Affect Outcomes on the Liver Transplant Waitlist. Transplantation 102:794-802
Benet, L Z; Liu, S; Wolfe, A R (2018) The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther 103:521-525
Schwartz, Janice B; Gallagher, J Christopher; Jorde, Rolf et al. (2018) Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. J Clin Endocrinol Metab 103:3278-3288
Qiao, Yu; Xu, Meng; Tao, Junyan et al. (2018) Oncogenic potential of N-terminal deletion and S45Y mutant ?-catenin in promoting hepatocellular carcinoma development in mice. BMC Cancer 18:1093

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