Introduction to Center and Core Missions The Harvard Digestive Disease Center is focused on the cell biology and function of epithelial cells of the alimentary tract, liver, and pancreas; and how epithelial biology manifests itself in mucosal immunity and allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract The Center aims to facilitate multidisciplinary research in this field by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in the Longwood Medical Area. We also aim to recruit new and established investigators into the fields of gastrointestinal biology. Our overarching mission is to foster better basic and translational science in fields related to digestive diseases by: 'Connecting people, 'creating opportunity, and ^extending resources. Shared intellectual and scientific resources to enhance this effort and the productivity of our research base are provided by four service Cores and an Administrative Core (see Figure 1-CoreC at the end of this section). Each Core provides the following general resources to the HDDC: Core Services Materials and Reagents Instrumentation and Equipment 'Expertise, Protocols, and Training Core-development research

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034854-27
Application #
8564997
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Project Start
1997-09-01
Project End
2015-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
27
Fiscal Year
2012
Total Cost
$138,398
Indirect Cost
$61,362
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Hong, Shangyu; Song, Wei; Zushin, Peter-James H et al. (2018) Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab 12:25-38
Aden, Konrad; Tran, Florian; Ito, Go et al. (2018) ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. J Exp Med 215:2868-2886
Smillie, Christopher S; Sauk, Jenny; Gevers, Dirk et al. (2018) Strain Tracking Reveals the Determinants of Bacterial Engraftment in the Human Gut Following Fecal Microbiota Transplantation. Cell Host Microbe 23:229-240.e5
Sallis, Benjamin F; Acar, Utkucan; Hawthorne, Kelsey et al. (2018) A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions. Front Immunol 9:2059
Li, Katherine; Strauss, Richard; Ouahed, Jodie et al. (2018) Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. J Pediatr Gastroenterol Nutr 67:45-52
Li, Yang; Fu, Tian-Min; Lu, Alvin et al. (2018) Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A 115:10845-10852
Morris, Hayley T; Fort, Loic; Spence, Heather J et al. (2018) Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis. J Pathol 245:337-348
Panchal, Pratik; Budree, Shrish; Scheeler, Alex et al. (2018) Correction to: Scaling Safe Access to Fecal Microbiota Transplantation: Past, Present, and Future. Curr Gastroenterol Rep 20:28
O'Connell, Amy E; Zhou, Fanny; Shah, Manasvi S et al. (2018) Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet 103:131-137
Allegretti, J R; Allegretti, A S; Phelps, E et al. (2018) Asymptomatic Clostridium difficile carriage rate post-fecal microbiota transplant is low: a prospective clinical and stool assessment. Clin Microbiol Infect 24:780.e1-780.e3

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