Introduction to Center and Core Missions The Harvard Digestive Disease Center is focused on the cell biology and function of epithelial cells of the alimentary tract, liver, and pancreas;and how epithelial biology manifests itself in mucosal immunity and allergy, innate host defense, digestion and absorption, the development of gastrointestinal neoplasia, and the many other functions of the Gl tract. The Center aims to facilitate multidisciplinary research in this field by providing technical resources, core services, scientific expertise, and an important meeting point to foster close scientific and intellectual relationships among independent investigators in Harvard-affiliated hospitals, the Harvard Medical School and adjacent research institutions in the Longwood Medical Area. We also aim to recruit new and established investigators to the field. Our overarching mission is to foster better basic and translational science in fields related to digestive diseases by: ?connecting people, 'creating opportunity, and 'extending resources. Shared intellectual and scientific resources to enhance this effort and the productivity of our research base are provided by four service Cores and an Administrative Core (see Figure 1-CoreB). Each Core provides the following general resources to the HDDC: ? Core Services ? Materials and Reagents ? Instrumentation and Equipment "Expertise, Protocols, and Training ? Core-development research Core B provides HDDC members with light and electron microscopy, resources, and scientific support essential for research in the digestive diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034854-28
Application #
8565041
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
28
Fiscal Year
2013
Total Cost
$236,836
Indirect Cost
$54,026
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Jirapinyo, Pichamol; Dayyeh, Barham K Abu; Thompson, Christopher C (2016) Gastrojejunal anastomotic reduction for weight regain in roux-en-y gastric bypass patients: physiological, behavioral, and anatomical effects of endoscopic suturing and sclerotherapy. Surg Obes Relat Dis 12:1810-1816
Ariyachet, Chaiyaboot; Tovaglieri, Alessio; Xiang, Guanjue et al. (2016) Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell Stem Cell 18:410-21
Mudde, Anne C A; Lexmond, Willem S; Blumberg, Richard S et al. (2016) Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models. World Allergy Organ J 9:23
Arabzadeh, Azadeh; Dupaul-Chicoine, Jeremy; Breton, Valérie et al. (2016) Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells. Gut 65:821-9
Magalhães, Ana Cristina; Ferreira, Ana Rita; Gomes, Sílvia et al. (2016) Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response. Sci Rep 6:26028
Bucci, Vanni; Tzen, Belinda; Li, Ning et al. (2016) MDSINE: Microbial Dynamical Systems INference Engine for microbiome time-series analyses. Genome Biol 17:121
Duncan, Daniel R; Amirault, Janine; Johnston, Nikki et al. (2016) Gastroesophageal Reflux Burden, Even in Children That Aspirate, Does Not Increase Pediatric Hospitalization. J Pediatr Gastroenterol Nutr 63:210-7
Gensollen, Thomas; Iyer, Shankar S; Kasper, Dennis L et al. (2016) How colonization by microbiota in early life shapes the immune system. Science 352:539-44
Mingozzi, Francesca; Spreafico, Roberto; Gorletta, Tatiana et al. (2016) Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors. EMBO Mol Med 8:1039-51
Cox, Andrew G; Hwang, Katie L; Brown, Kristin K et al. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol 18:886-96

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