The Digestive Disease Research Core Center at UNC has had a biostatistical core since the center was established in 1985. The name, the directors, and the mission ofthe core have changed over time in response to evolution in the needs and research interests of members. The Biostatistics and Data Management Core has been extensively used by basic science, epidemiology, clinical outcomes and clinical investigators who are CGIBD members and associate members. Furthermore, the Biostatistics and Data Management Core provides a unique national resource to Digestive Disease investigators outside our Center. The Biostatistics and Data Management Core provides state-of-the-art data services and consultation. As described in detaU in the sections that follow, the core assists with the collection, analysis and integration of biological and epidemiological data using techniques of computer science and statistics. We provide assistance vnth database maintenance, web applications, data capture, quality control, data analysis, and statistics. The Core provides an interface between basic scientists and informatics specialists to support translational research. Importantly, the core provides essential services to the large group of clinical epidemiologists who are members of our center. The core is fully equipped and staffed with a suite of offices in the recently opened Bioinformatics Building. For the past decade the CGIBD Biostatistics and Data Management Core has served as the Data Management Center for the Crohn's and Colitis Foundation of America (CCFA) Clinical Alliance. The purpose ofthe Alliance is to conduct multi-center randomized trials of IBD therapy. As the Data Management Center it is our responsibUity to assist in study design and protocol development. We create the case report forms, data entry routines, quality control measures, and analysis plans. Our biostatistician performs all data analyses. The Data Management Center is an excellent example of cooperation between a research university, a private foundation, and an NIH Digestive Disease Research Core Center. We were able to secure the contract v^th the CCFA because ofthe expertise and infrastructure that we developed through our Digestive Disease Research Core Center. In turn, our center members have benefited by the expertise and extra capacity that we have developed through CCFA funding. CGIBD members and associates derive the benefit of a fuU time biostatistician and data management team at their disposal. They also benefit from the equipment, tools and techniques that we have assembled. However, the CGIBD pays for only a small portion ofthe costs associated with the operation ofthe Data Management Center. The bulk ofthe costs are paid for by large research grants and contracts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK034987-25
Application #
7764468
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Project Start
2010-03-15
Project End
2014-11-30
Budget Start
2010-03-15
Budget End
2010-11-30
Support Year
25
Fiscal Year
2010
Total Cost
$111,211
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Walker, Miriam Y; Pratap, Siddharth; Southerland, Janet H et al. (2017) Role of oral and gut microbiome in nitric oxide-mediated colon motility. Nitric Oxide :
Bartelt, Luther A; Bolick, David T; Mayneris-Perxachs, Jordi et al. (2017) Cross-modulation of pathogen-specific pathways enhances malnutrition during enteric co-infection with Giardia lamblia and enteroaggregative Escherichia coli. PLoS Pathog 13:e1006471
Dellon, Evan S; Veerappan, Ranjitha; Selitsky, Sara R et al. (2017) A Gene Expression Panel is Accurate for Diagnosis and Monitoring Treatment of Eosinophilic Esophagitis in Adults. Clin Transl Gastroenterol 8:e74
Peery, Anne F; Keku, Temitope O; Addamo, Cassandra et al. (2017) Colonic Diverticula Are Not Associated With Mucosal Inflammation or Chronic Gastrointestinal Symptoms. Clin Gastroenterol Hepatol :
Hirsch, Matthew L; Conatser, Laura M; Smith, Sara M et al. (2017) AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis. Sci Rep 7:17840
Arnold, Jason W; Monteagudo-Mera, Andrea; Altermann, Eric et al. (2017) Genome Sequences of Potential Probiotic Lactobacillus rhamnosus Isolates from Human Infants. Genome Announc 5:
Fedirko, Veronika; McKeown-Eyssen, Gail; Serhan, Charles N et al. (2017) Plasma lipoxin A4 and resolvin D1 are not associated with reduced adenoma risk in a randomized trial of aspirin to prevent colon adenomas. Mol Carcinog 56:1977-1983
Pollard, Katharine L; Campbell, Christina; Squires, Megan et al. (2017) Seasonal Association of Pediatric Functional Abdominal Pain Disorders and Anxiety. J Pediatr Gastroenterol Nutr :
Kochar, Bharati; Long, Millie D; Galanko, Joseph et al. (2017) Inflammatory Bowel Disease is Similar in Patients with Older Onset and Younger Onset. Inflamm Bowel Dis 23:1187-1194
Asher, Gary N; Xie, Ying; Moaddel, Ruin et al. (2017) Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers. J Clin Pharmacol 57:185-193

Showing the most recent 10 out of 890 publications