Although the CGIBD does not have a 'clinical core', the Biostatistics and Bioinformatics Core serves a similar purpose. The CGIBD has had a statistical core since the center was established in 1985, but the name of the core, the directors and the services have evolved over time as the field has matured and the needs of members have changed. The core assists with the collection, analysis and integration of biological and epidemiological data using techniques of computer science and statistics. The core provides assistance with database implementation and maintenance, web applications, validated and secure data capture, quality control, data analysis, and statistical analysis. We offer full collaboration on sound statistical study design, study process engineering, data model development, system design and implementation. This leads to secure and accurate data capture and management, linking of various data types and sources, and data extraction and reporting for analytics. The Core provides an interface between basic scientists and informatics specialists to support translational research. Importantly, the core provides essential services to the large group of clinical epidemiologists who are members of our center. The Core is co-directed by Kristen Anton who is the Director of Bioinformatics at UNC. She has developed and maintained data capture, management and integration systems for clinical research registries, clinical trials and prevention studies, as well as genomics and proteomics projects associated with epidemiological studies, for more than twenty years. Robert Sandler serves as the other co-director and he brings expertise in study design and analysis for clinical and epidemiological studies. The Core has a biostatistician, epidemiologist, and programmers. The core offers: consultation, informatics and data management services, programming, statistical analysis and training and education. The infrastructure created by this core has been leveraged by the CGIBD which is now the data management center for the CCFA Clinical Alliance, SHARE (Sinai-Helmsley Alliance for Research Excellence), and CCFA Partners (an internet cohort of 12,000 IBD patients). Any new CGIBD study may take advantage of the infrastructure, software tools and informatics expertise already in place in the Core, eliminating the need for each study to budget for hardware, software licenses and personnel expert in the necessary areas of system development and data management.

Public Health Relevance

Conducting high quality clinical translational and epidemiological research requires a sophisticated bioinformatics platform to collect, store and analyze the data. Investigators need ready access to consultation in study design, data management and biostatistics. The Biostatistics and Bioinformatics core has the personnel and expertise to enhance the quality and the integrity of research conducted by CGIBD members.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Azcarate-Peril, M Andrea; Butz, Natasha; Cadenas, Maria Belen et al. (2018) An Attenuated Salmonella enterica Serovar Typhimurium Strain and Galacto-Oligosaccharides Accelerate Clearance of Salmonella Infections in Poultry through Modifications to the Gut Microbiome. Appl Environ Microbiol 84:
Carlson, Alexander L; Xia, Kai; Azcarate-Peril, M Andrea et al. (2018) Infant Gut Microbiome Associated With Cognitive Development. Biol Psychiatry 83:148-159
Lee, Mi Kyeong; Carnes, Megan U; Butz, Natasha et al. (2018) Exposures Related to House Dust Microbiota in a U.S. Farming Population. Environ Health Perspect 126:067001
Evon, D M; Amador, J; Stewart, P et al. (2018) Psychometric properties of the PROMIS short form measures in a U.S. cohort of 961 patients with chronic hepatitis C prescribed direct acting antiviral therapy. Aliment Pharmacol Ther 47:1001-1011
Jones, Roshonda B; Fodor, Anthony A; Peery, Anne F et al. (2018) An Aberrant Microbiota is not Strongly Associated with Incidental Colonic Diverticulosis. Sci Rep 8:4951
Busch, Evan L; Galanko, Joseph A; Sandler, Robert S et al. (2018) Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. Sci Rep 8:9470
Eluri, Swathi; Cross, Raymond K; Martin, Christopher et al. (2018) Inflammatory Bowel Diseases Can Adversely Impact Domains of Sexual Function Such as Satisfaction with Sex Life. Dig Dis Sci 63:1572-1582
Dellon, Evan S; Selitsky, Sara R; Genta, Robert M et al. (2018) Gene expression-phenotype associations in adults with eosinophilic esophagitis. Dig Liver Dis 50:804-811
Rogala, Allison R; Schoenborn, Alexi A; Fee, Brian E et al. (2018) Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice. Dis Model Mech 11:
Li, Feng; Kakoki, Masao; Smid, Marcela et al. (2018) Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice. Hypertension 71:894-903

Showing the most recent 10 out of 944 publications