The overall mission ofthe UNC Center for Gastrointestinal Biology and Disease (CGIBD) is to promote and enhance multidisciplinary research in digestive diseases. This mission is accomplished in part, through core laboratories that provide laboratory services, training, and technical support to center members. The Histology Core supports CGIBD's mission by providing essential histopathological services to members conducting digestive diseases research. The services provided by the Core include consultation during the planning phase of experiments, analysis of human and mouse intestine, liver, pancreas, and other GI related tissue specimens for histology and immunohistochemistry. We also provide access to four fluorescent microscopes; a Zeiss AXio Imager, a Zeiss AXio Primo Star Microscope and Olympus IX71 and IX81 inverted fluorescence microscopes. In addition, the Core provides digital slide scanning and image analysis services in partnership with the UNC Translational Pathology Laboratory (TPL; https://tpl.med.unc.edu/l A new service is to provide brightfield and fluorescent live cell imaging to users. The main goal of TPL is to take laboratory research discoveries into the realm of clinical care in a timely manner. The partnership wdth the TPL is beneficial because it allows the CGIBD Histology Core to provide cutting edge digital imaging services to Center members. The Core personnel include a faculty director, a histotechnician, and research assistants who vsdll oversee the slide digitization process. The Core Director has broad expertise in histology and cancer biomarkers and oversees the administration ofthe Core. The histotechnician has over 15 years experience in histopathology and is responsible for sample preparation and processing for histological analysis and digital imaging on a fee for service basis. She has two research assistants who help her with these duties. As can be seen from the Core Use report, the Core is heavily utilized by Center members and other researchers at UNC

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034987-34
Application #
9605034
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
2020-03-14
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
34
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Kochar, Bharati; Barnes, Edward L; Long, Millie D et al. (2018) Depression Is Associated With More Aggressive Inflammatory Bowel Disease. Am J Gastroenterol 113:80-85
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Schulfer, Anjelique F; Battaglia, Thomas; Alvarez, Yelina et al. (2018) Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. Nat Microbiol 3:234-242
Dong, Jing; Buas, Matthew F; Gharahkhani, Puya et al. (2018) Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants. Gastroenterology 154:1273-1281.e3
Azcarate-Peril, M Andrea; Butz, Natasha; Cadenas, Maria Belen et al. (2018) An Attenuated Salmonella enterica Serovar Typhimurium Strain and Galacto-Oligosaccharides Accelerate Clearance of Salmonella Infections in Poultry through Modifications to the Gut Microbiome. Appl Environ Microbiol 84:
Carlson, Alexander L; Xia, Kai; Azcarate-Peril, M Andrea et al. (2018) Infant Gut Microbiome Associated With Cognitive Development. Biol Psychiatry 83:148-159
Lee, Mi Kyeong; Carnes, Megan U; Butz, Natasha et al. (2018) Exposures Related to House Dust Microbiota in a U.S. Farming Population. Environ Health Perspect 126:067001
Evon, D M; Amador, J; Stewart, P et al. (2018) Psychometric properties of the PROMIS short form measures in a U.S. cohort of 961 patients with chronic hepatitis C prescribed direct acting antiviral therapy. Aliment Pharmacol Ther 47:1001-1011
Jones, Roshonda B; Fodor, Anthony A; Peery, Anne F et al. (2018) An Aberrant Microbiota is not Strongly Associated with Incidental Colonic Diverticulosis. Sci Rep 8:4951
Busch, Evan L; Galanko, Joseph A; Sandler, Robert S et al. (2018) Lifestyle Factors, Colorectal Tumor Methylation, and Survival Among African Americans and European Americans. Sci Rep 8:9470

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