The Morphology Core Facility provides instrumentation and technical expertise for the preparation, acquisition and analysis of images of cells and tissues at both the light and electron microscopic level. Given the cost of such instrumentation and the high level of technical expertise required to perform these investigational techniques, this Core was established to ensure the availability of these techniques for Center members. In recognition of the broad usefulness of this Core facility, the School of Medicine has partnered with the Liver Center by making ongoing, major investments to ensure that the facility remains state-of-the-art. The Morphology Core offers the following specific activities and services, plus associated training and technical support: 1) confocal microscopy, 2) epifluorescence microscopy, including quantitative and ratio imaging, 3) multiphoton microscopy, 4) electron microscopy, and 5) time lapse microscopy and image processing and analysis. Over half of the members of the Liver Center used this core facility and the core was used in over one hundred publications during the current award period, reflecting the usefulness and importance of this resource for the mission of the Center.
The primary focus of the Yale Liver Center is the study of liver structure, function and disease. The Morphology Core plays a key role in this endeavor by permitting direct visualization of the structure and function of the liver and its components at the cellular and subcellular level. This resource in turn helps investigators to better understand the function of cells within the liver in normal and disease states.
|Henao-Mejia, Jorge; Williams, Adam; Rongvaux, Anthony et al. (2016) Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System. Cold Spring Harb Protoc 2016:pdb.prot090704|
|Nair, Shiny; Branagan, Andrew R; Liu, Jun et al. (2016) Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma. N Engl J Med 374:555-61|
|Collins, Kevin M; Bode, Addys; Fernandez, Robert W et al. (2016) Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition. Elife 5:|
|Nagarajan, Arvindhan; Petersen, Max C; Nasiri, Ali R et al. (2016) MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun 7:12639|
|Wang, Baisheng; Boeckel, GÃ¶ran R; Huynh, Larry et al. (2016) Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. PLoS One 11:e0161414|
|Fiorotto, Romina; Villani, Ambra; Kourtidis, Antonis et al. (2016) The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology 64:2118-2134|
|Wree, Alexander; Mehal, Wajahat Z; Feldstein, Ariel E (2016) Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis. Semin Liver Dis 36:27-36|
|Sack, Jordan; Garcia-Tsao, Guadalupe (2016) Variceal Hemorrhage in a Patient With Hepatitis C Virus Cirrhosis in Whom Liver Synthetic Function had Normalized After Viral Elimination. Hepatology 63:1733-5|
|Nguyen, Nghia H; Yee, Brittany E; Chang, Christine et al. (2016) Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis. BMJ Open Gastroenterol 3:e000066|
|Petersen, Max C; Madiraju, Anila K; Gassaway, Brandon M et al. (2016) Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest 126:4361-4371|
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