The Morphology Core Facility provides instrumentation and technical expertise for the preparation, acquisition and analysis of images of cells and tissues at both the light and electron microscopic level. Given the cost of such instrumentation and the high level of technical expertise required to perform these investigational techniques, this Core was established to ensure the availability of these techniques for Center members. In recognition of the broad usefulness of this Core facility, the School of Medicine has partnered with the Liver Center by making ongoing, major investments to ensure that the facility remains state-of-the-art. The Morphology Core offers the following specific activities and services, plus associated training and technical support: 1) confocal microscopy, 2) epifluorescence microscopy, including quantitative and ratio imaging, 3) multiphoton microscopy, 4) electron microscopy, and 5) time lapse microscopy and image processing and analysis. Over half of the members of the Liver Center used this core facility and the core was used in over one hundred publications during the current award period, reflecting the usefulness and importance of this resource for the mission of the Center.
The primary focus of the Yale Liver Center is the study of liver structure, function and disease. The Morphology Core plays a key role in this endeavor by permitting direct visualization of the structure and function of the liver and its components at the cellular and subcellular level. This resource in turn helps investigators to better understand the function of cells within the liver in normal and disease states.
|Manfredo Vieira, S; Hiltensperger, M; Kumar, V et al. (2018) Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 359:1156-1161|
|Lawan, Ahmed; Min, Kisuk; Zhang, Lei et al. (2018) Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Diabetes 67:624-635|
|Franca, Andressa; Filho, Antonio Carlos Melo Lima; Guerra, Mateus T et al. (2018) Effects of endotoxin on type 3 inositol 1,4,5-trisphosphate receptor in human cholangiocytes. Hepatology :|
|Liu, Chune; Yang, Zhihong; Wu, Jianguo et al. (2018) Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis. Hepatology 67:1768-1783|
|Brivio, Simone; Cadamuro, Massimiliano; Fabris, Luca et al. (2018) Molecular Mechanisms Driving Cholangiocarcinoma Invasiveness: An Overview. Gene Expr 18:31-50|
|Cox, Carly S; McKay, Sharen E; Holmbeck, Marissa A et al. (2018) Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling. Cell Metab 28:776-786.e5|
|Madiraju, Anila K; Qiu, Yang; Perry, Rachel J et al. (2018) Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nat Med 24:1384-1394|
|Schmitz, Corinna; Noels, Heidi; El Bounkari, Omar et al. (2018) Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis. FASEB J 32:4428-4443|
|Pan, Qiong; Zhang, Xiaoxun; Zhang, Liangjun et al. (2018) Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Gastroenterology 155:1578-1592.e16|
|Jakab, Sofia Simona; Garcia-Tsao, Guadalupe (2018) Screening and Surveillance of Varices in Patients With Cirrhosis. Clin Gastroenterol Hepatol :|
Showing the most recent 10 out of 763 publications