The Morphology Core Facility provides instrumentation and technical expertise for the preparation, acquisition and analysis of images of cells and tissues at both the light and electron microscopic level. Given the cost of such instrumentation and the high level of technical expertise required to perform these investigational techniques, this Core was established to ensure the availability of these techniques for Center members. In recognition of the broad usefulness of this Core facility, the School of Medicine has partnered with the Liver Center by making ongoing, major investments to ensure that the facility remains state-of-the-art. The Morphology Core offers the following specific activities and services, plus associated training and technical support: 1) confocal microscopy, 2) epifluorescence microscopy, including quantitative and ratio imaging, 3) multiphoton microscopy, 4) electron microscopy, and 5) time lapse microscopy and image processing and analysis. Over half of the members of the Liver Center used this core facility and the core was used in over one hundred publications during the current award period, reflecting the usefulness and importance of this resource for the mission of the Center.

Public Health Relevance

The primary focus of the Yale Liver Center is the study of liver structure, function and disease. The Morphology Core plays a key role in this endeavor by permitting direct visualization of the structure and function of the liver and its components at the cellular and subcellular level. This resource in turn helps investigators to better understand the function of cells within the liver in normal and disease states.

National Institute of Health (NIH)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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Yale University
New Haven
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Birkenfeld, Andreas L; Shulman, Gerald I (2014) Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59:713-23
Cai, Shi-Ying; Mennone, Albert; Soroka, Carol J et al. (2014) Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice. Am J Physiol Gastrointest Liver Physiol 306:G670-6
Kuo, Ivana Y; DesRochers, Teresa M; Kimmerling, Erica P et al. (2014) Cyst formation following disruption of intracellular calcium signaling. Proc Natl Acad Sci U S A 111:14283-8
Hedl, Matija; Zheng, Shasha; Abraham, Clara (2014) The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways. J Immunol 192:5924-32
Cai, Shi-Ying; Mennone, Albert; Soroka, Carol J et al. (2014) All-trans-retinoic acid improves cholestasis in ?-naphthylisothiocyanate-treated rats and Mdr2-/- mice. J Pharmacol Exp Ther 349:94-8
Hedl, Matija; Abraham, Clara (2014) A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1. Proc Natl Acad Sci U S A 111:13451-6
Strazzabosco, Mario; Fabris, Luca (2014) Neural cell adhesion molecule and polysialic acid in ductular reaction: the puzzle is far from completed, but the picture is becoming more clear. Hepatology 60:1469-72
Amaya, Maria J; Oliveira, Andre G; Guimaraes, Erika S et al. (2014) The insulin receptor translocates to the nucleus to regulate cell proliferation in liver. Hepatology 59:274-83
Chen, Jianxin; Wong, Serena; Nathanson, Michael H et al. (2014) Evaluation of Barrett esophagus by multiphoton microscopy. Arch Pathol Lab Med 138:204-12
Hedl, Matija; Lahiri, Amit; Ning, Kaida et al. (2014) Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele. Immunity 40:734-46

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