The Clinical-Translational Core provides an infrastructure for patient-oriented research by streamlining regulatory and compliance processes, obtaining and storing high-quality samples linked to extensive clinical phenotypic information, offering expert consultation in the design and implementation of patient-oriented trials, and supplying statistical expertise for application of innovative analytic methods in translational and patient-oriented research. The Core was established to facilitate the performance of patient oriented research to Core members. The Clinical-Translational Core has been extremely effective in accomplishing its goals, generating a large number of original publications and establishing numerous collaborations with facilities and investigators that have increased or supplemented the available services (e.g. the Office of Research Services of the Yale Center for Clinical Investigation that has been assisting Liver Center investigators, at no cost, in preparing and submitting new research projects), and provide additional sources of support for Core activities (support for inpatient data collection from the National Consortium for the Study of Endstage Liver Disease) as well as increasing the number of core members. The Clinical-Translational Core offers the following specific activities and services, plus associated training and technical support: 1) a resource (Clinical Core Coordinator) that facilitates regulatory processes (obtaining and maintaining IRB approval for the performance of patient-oriented research), 2) clinical registries consisting mainly of a patient (1,875 unique patients), and a sample registry (blood samples from 939 unique patients), as well as disease-specific databases that have been collected by different center investigators over the years, 3) statistical support, including study design and implementation and data analysis.

Public Health Relevance

The primary focus of the Yale Liver Center is the study of liver structure, function, and disease. The Clinical-Translational Core plays a key role in this endeavor by facilitating the performance of translational patient-oriented research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK034989-33
Application #
9135329
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
33
Fiscal Year
2016
Total Cost
$50,811
Indirect Cost
$20,294
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Henao-Mejia, Jorge; Williams, Adam; Rongvaux, Anthony et al. (2016) Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System. Cold Spring Harb Protoc 2016:pdb.prot090704
Nair, Shiny; Branagan, Andrew R; Liu, Jun et al. (2016) Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma. N Engl J Med 374:555-61
Collins, Kevin M; Bode, Addys; Fernandez, Robert W et al. (2016) Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition. Elife 5:
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Wang, Baisheng; Boeckel, Göran R; Huynh, Larry et al. (2016) Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. PLoS One 11:e0161414
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Nguyen, Nghia H; Yee, Brittany E; Chang, Christine et al. (2016) Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis. BMJ Open Gastroenterol 3:e000066
Petersen, Max C; Madiraju, Anila K; Gassaway, Brandon M et al. (2016) Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest 126:4361-4371

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