The Clinical-Translational Core provides an infrastructure for patient-oriented research by streamlining regulatory and compliance processes, obtaining and storing high-quality samples linked to extensive clinical phenotypic information, offering expert consultation in the design and implementation of patient-oriented trials, and supplying statistical expertise for application of innovative analytic methods in translational and patient-oriented research. The Core was established to facilitate the performance of patient oriented research to Core members. The Clinical-Translational Core has been extremely effective in accomplishing its goals, generating a large number of original publications and establishing numerous collaborations with facilities and investigators that have increased or supplemented the available services (e.g. the Office of Research Services of the Yale Center for Clinical Investigation that has been assisting Liver Center investigators, at no cost, in preparing and submitting new research projects), and provide additional sources of support for Core activities (support for inpatient data collection from the National Consortium for the Study of Endstage Liver Disease) as well as increasing the number of core members. The Clinical-Translational Core offers the following specific activities and services, plus associated training and technical support: 1) a resource (Clinical Core Coordinator) that facilitates regulatory processes (obtaining and maintaining IRB approval for the performance of patient-oriented research), 2) clinical registries consisting mainly of a patient (1,875 unique patients), and a sample registry (blood samples from 939 unique patients), as well as disease-specific databases that have been collected by different center investigators over the years, 3) statistical support, including study design and implementation and data analysis.

Public Health Relevance

The primary focus of the Yale Liver Center is the study of liver structure, function, and disease. The Clinical-Translational Core plays a key role in this endeavor by facilitating the performance of translational patient-oriented research.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-8)
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Yale University
New Haven
United States
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Henao-Mejia, Jorge; Williams, Adam; Rongvaux, Anthony et al. (2016) Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System. Cold Spring Harb Protoc 2016:pdb.prot090704
Nair, Shiny; Branagan, Andrew R; Liu, Jun et al. (2016) Clonal Immunoglobulin against Lysolipids in the Origin of Myeloma. N Engl J Med 374:555-61
Collins, Kevin M; Bode, Addys; Fernandez, Robert W et al. (2016) Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition. Elife 5:
Nagarajan, Arvindhan; Petersen, Max C; Nasiri, Ali R et al. (2016) MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nat Commun 7:12639
Wang, Baisheng; Boeckel, Göran R; Huynh, Larry et al. (2016) Neuronal Calcium Sensor 1 Has Two Variants with Distinct Calcium Binding Characteristics. PLoS One 11:e0161414
Fiorotto, Romina; Villani, Ambra; Kourtidis, Antonis et al. (2016) The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity. Hepatology 64:2118-2134
Wree, Alexander; Mehal, Wajahat Z; Feldstein, Ariel E (2016) Targeting Cell Death and Sterile Inflammation Loop for the Treatment of Nonalcoholic Steatohepatitis. Semin Liver Dis 36:27-36
Sack, Jordan; Garcia-Tsao, Guadalupe (2016) Variceal Hemorrhage in a Patient With Hepatitis C Virus Cirrhosis in Whom Liver Synthetic Function had Normalized After Viral Elimination. Hepatology 63:1733-5
Petersen, Max C; Madiraju, Anila K; Gassaway, Brandon M et al. (2016) Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J Clin Invest 126:4361-4371
Nguyen, Nghia H; Yee, Brittany E; Chang, Christine et al. (2016) Tolerability and effectiveness of sofosbuvir and simeprevir in the post-transplant setting: systematic review and meta-analysis. BMJ Open Gastroenterol 3:e000066

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