The purposes of the Einstein Liver Research Center (LRC) are to provide strong leadership and direction, catalyze creative basic and translational liver-related research, sustain a collaborative state-of-the-art infrastructure ad provide tools and approaches to facilitate the discovery and translation of novel research findings into improvements in treatment and prevention of liver disorders. The Center supports a group of established investigators actively conducting quality research that relate to liver pathobiology and fit into one of our three research foci: 1) Liver Regeneration, Cell Growth Control and Repopulation of the Liver by Transplanted Cells;2) Pathobiology of Hepatic Transport and Trafficking;3) Hepatic Metabolism, Inflammation, and Steatohepatitis. By bringing excellent basic scientists into disease-related research, together with hepatologlsts interested in mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. Our basic philosophy has been and continues to be, to seek out expertise and help from each other in an open ended fashion in our quest for new understanding of liver structure-function and disease. Core facilities are: A) Animal Models, Stem Cells and Cell Therapy;B) Molecular Biology and Next Generation Technologies;C) Imaging and Cell Structure;D) Genetic Engineering and Gene Therapy;and an Administrative Core. A Clinical Component has been added to the Center provide a platform to bridge new basic research findings to translational advances in the study and treatment of human liver diseases. The Center is directed by the Principal Investigator (Dr. Allan W. Wolkoff) and Associate Director (Dr. David A. Shafritz), governed by an Executive Committee and advised and reviewed by an external Scientific Advisory Committee. The importance of the Liver Research Center to the College of Medicine and hospital center has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by Dean Allen Spiegel, and Montefiore CEO Dr. Steven Safyer.

Public Health Relevance

It is estimated that over 30 million Americans have a liver disorder;further, liver disease is one of the ten leading causes of death in the United States. Although advances have been made in diagnosis and treatment of liver diseases, there is still much to be learned. The Liver Research Center at Einstein provides a multidisciplinary approach to the study of liver disease by integrating basic and clinical research efforts to foster development of new insights and paradigms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK041296-26
Application #
8701592
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (J2))
Program Officer
Podskalny, Judith M,
Project Start
1997-06-01
Project End
2019-06-30
Budget Start
2014-08-15
Budget End
2015-06-30
Support Year
26
Fiscal Year
2014
Total Cost
$1,252,500
Indirect Cost
$502,500
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Lim, Jihyeon; Liu, Zhongbo; Apontes, Pasha et al. (2014) Dual mode action of mangiferin in mouse liver under high fat diet. PLoS One 9:e90137
Wang, Wen-Jun; Murray, John W; Wolkoff, Allan W (2014) Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins. Drug Metab Dispos 42:62-9
Yovchev, Mladen I; Xue, Yuhua; Shafritz, David A et al. (2014) Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes. Hepatology 59:284-95
Yuan, Fei; Snapp, Erik L; Novikoff, Phyllis M et al. (2014) Human liver cell trafficking mutants: characterization and whole exome sequencing. PLoS One 9:e87043
Mukhopadhyay, Aparna; Quiroz, Jose A; Wolkoff, Allan W (2014) Rab1a regulates sorting of early endocytic vesicles. Am J Physiol Gastrointest Liver Physiol 306:G412-24
Viswanathan, Preeti; Kapoor, Sorabh; Kumaran, Vinay et al. (2014) Etanercept blocks inflammatory responses orchestrated by TNF-? to promote transplanted cell engraftment and proliferation in rat liver. Hepatology 60:1378-88
Bahde, Ralf; Kapoor, Sorabh; Gupta, Sanjeev (2014) Nonselective inhibition of prostaglandin-endoperoxide synthases by naproxen ameliorates acute or chronic liver injury in animals. Exp Mol Pathol 96:27-35
Rogler, Leslie E; Kosmyna, Brian; Moskowitz, David et al. (2014) Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia. Hum Mol Genet 23:368-82
Lajoie, Patrick; Fazio, Elena N; Snapp, Erik L (2014) Approaches to imaging unfolded secretory protein stress in living cells. Endoplasmic Reticulum Stress Dis 1:27-39
Kapoor, Sorabh; Berishvili, Ekaterine; Bandi, Sriram et al. (2014) Ischemic preconditioning affects long-term cell fate through DNA damage-related molecular signaling and altered proliferation. Am J Pathol 184:2779-90

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