The Administrative Core is the central command and operations post of the Liver Pathobiology and Gene Therapy Research Core Center. The Core maintains and manages the fundamental infrastructure necessary to sustain and strengthen basic translational and clinical liver-related research at the Center. All planning, communications and activities of the Center go through this office. Dr. Allan W. Wolkoff, Director of the Center is Director of the Administrative Core. He is assisted by the Associate Director, David A. Shafritz, who oversees operation of the Research Core Facilities and our Administrator, who manages the Core Center grant and grants submitted by Center Investigators. She assists in preparation of all budgets and personnel assigned to grants flowing through the Center;in addition, she manages expenditures by the Core Facilities, Pilot and Feasibility Studies and the Enrichment Program. Four key committees, 1) the Executive Committee, 2) the Scientific Advisory Committee, 3) the Core Facilities Management Committee and the 4) Educational and Enrichment Committee work to ensure smooth operations of the Center and assure outstanding program management and effective operation. Working together, under the outstanding vision and leadership of the Director, and with continued support from NIDDK, Albert Einstein College of Medicine and Montefiore Medical Center, the Pathobiology and Gene Therapy Research Core Center enthusiastically looks forward to achieving major advances in liver pathobiology and treatment of liver diseases, during the next funding period.
It is estimated that over 30 million Americans have a liver disorder;further, liver disease is one of the ten leading causes of death in the United States. Although advances have been made in diagnosis and treatment of liver diseases, there is still much to be learned. The Liver Research Center at Einstein provides a multidisciplinary approach to the study of liver disease by integrating basic and clinical research efforts to foster development of new insights and paradigms.
|Lim, Jihyeon; Liu, Zhongbo; Apontes, Pasha et al. (2014) Dual mode action of mangiferin in mouse liver under high fat diet. PLoS One 9:e90137|
|Wang, Wen-Jun; Murray, John W; Wolkoff, Allan W (2014) Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins. Drug Metab Dispos 42:62-9|
|Yovchev, Mladen I; Xue, Yuhua; Shafritz, David A et al. (2014) Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes. Hepatology 59:284-95|
|Yuan, Fei; Snapp, Erik L; Novikoff, Phyllis M et al. (2014) Human liver cell trafficking mutants: characterization and whole exome sequencing. PLoS One 9:e87043|
|Mukhopadhyay, Aparna; Quiroz, Jose A; Wolkoff, Allan W (2014) Rab1a regulates sorting of early endocytic vesicles. Am J Physiol Gastrointest Liver Physiol 306:G412-24|
|Viswanathan, Preeti; Kapoor, Sorabh; Kumaran, Vinay et al. (2014) Etanercept blocks inflammatory responses orchestrated by TNF-? to promote transplanted cell engraftment and proliferation in rat liver. Hepatology 60:1378-88|
|Bahde, Ralf; Kapoor, Sorabh; Gupta, Sanjeev (2014) Nonselective inhibition of prostaglandin-endoperoxide synthases by naproxen ameliorates acute or chronic liver injury in animals. Exp Mol Pathol 96:27-35|
|Rogler, Leslie E; Kosmyna, Brian; Moskowitz, David et al. (2014) Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia. Hum Mol Genet 23:368-82|
|Lajoie, Patrick; Fazio, Elena N; Snapp, Erik L (2014) Approaches to imaging unfolded secretory protein stress in living cells. Endoplasmic Reticulum Stress Dis 1:27-39|
|Kapoor, Sorabh; Berishvili, Ekaterine; Bandi, Sriram et al. (2014) Ischemic preconditioning affects long-term cell fate through DNA damage-related molecular signaling and altered proliferation. Am J Pathol 184:2779-90|
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