The goal of the Molecular Biology and Next Generation Technologies (MBNGT) Core has been, and will continue to be, to provide essential molecular biology and genetic services in advanced technology areas, and to pioneer new areas of research that promote discovery, hypothesis-driven science and innovation to investigators in the Liver Research Center (LRC).
The specific aims of the MBNGT Core are predominantly two-fold. (1) To continue to provide basic services through the availability of dedicated space in the LRC with shared equipment unavailable in individual investigators laboratories. In addition, the Core Manager will continue to provide individualized teaching and service to facilitate the adaptation of molecular genetic assays and procedures to the wide spectrum of students, postdoctoral fellows, residents, fellows, physician-scientists and principle investigators incorporating these assays into their research. (2) To introduce new services primarily related to the dynamic technologies being rapidly employed in research based on massively parallel sequencing (aka. Next Generation Sequencing (NGS)) and advances in bioinformatics. The MBNGT Core will provide teaching and services allowing LRC scientists to access NGS through preparation of specialized libraries, isolation of exosomes and microRNA for deep sequencing and characterization of the microbiome. The close proximity of the MBNGT facility and the availability of staff to teach, advise experimental approaches, perform highly technical procedures and help interpret complex data sets will serve to enrich the research performed in the LRC.

Public Health Relevance

It is estimated that over 30 million Americans have a liver disorder;further, liver disease is one of the ten leading causes of death in the United States. Although advances have been made in diagnosis and treatment of liver diseases, there is still much to be learned. The Liver Research Center at Einstein provides a multidisciplinary approach to the study of liver disease by integrating basic and clinical research efforts to foster development of new insights and paradigms.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK041296-26
Application #
8743567
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (J2))
Project Start
2014-08-15
Project End
2019-06-30
Budget Start
2014-08-15
Budget End
2015-06-30
Support Year
26
Fiscal Year
2014
Total Cost
$182,606
Indirect Cost
$73,261
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Brodin, N Patrik; Chen, Yong; Yaparpalvi, Ravindra et al. (2016) Dosimetry Formalism and Implementation of a Homogenous Irradiation Protocol to Improve the Accuracy of Small Animal Whole-Body Irradiation Using a 137Cs Irradiator. Health Phys 110:S26-38
Ilyas, Ghulam; Zhao, Enpeng; Liu, Kun et al. (2016) Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β. J Hepatol 64:118-27
Yuan, Ziqiang; Sánchez Claros, Carmen; Suzuki, Masako et al. (2016) Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis. Oncotarget 7:12633-50
Taylor, Sarah A; Vittorio, Jennifer M; Martinez, Mercedes et al. (2016) Anakinra-Induced Acute Liver Failure in an Adolescent Patient with Still's Disease. Pharmacotherapy 36:e1-4
Dondossola, Eleonora; Dobroff, Andrey S; Marchiò, Serena et al. (2016) Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors. Proc Natl Acad Sci U S A 113:2223-8
Fomenko, Ekaterina Vladimirovna; Chi, Yuling (2016) Mangiferin modulation of metabolism and metabolic syndrome. Biofactors 42:492-503
Yu, Yang; Guerrero, Candace R; Liu, Shuo et al. (2016) Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease. Mol Cell Proteomics 15:810-7
Merlin, Simone; Bhargava, Kuldeep K; Ranaldo, Gabriella et al. (2016) Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy. Am J Pathol 186:539-51
Roy-Chowdhury, Jayanta; Schilsky, Michael L (2016) Gene therapy of Wilson disease: A ""golden"" opportunity using rAAV on the 50th anniversary of the discovery of the virus. J Hepatol 64:265-7
Kerzerho, Jerome; McIlvaine, Elizabeth J; Anthony, Patricia et al. (2016) Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr 71:172-80

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