Abstract

The overall objective of the Animal Models Core is to provide expertise to members of the CURE: Digestive Diseases Research Core Center (CURE: DDRCC) for in vivo characterization of normal and pathophysiological mechanisms of hormonal and neural regulation of gastrointestinal (GI) function and brain-gut interactions in rodents. The specific objectives are to provide CURE: DDRCC investigators access to: (1) in vivo experimental models to assess gastric and intestinal function in rats and mice; (2) specialized facilities and equipment to measure GI secretions, motor function, blood flow, resistance of the mucosa to injury and functional mapping of neuronal activity at the cellular level; (3) methods for in vivo administration of peptides, neurotransmitters, and drugs, sampling blood and body fluids, and tissue collection; (4) methods to assess afferent and efferent arms of the neural pathways involved in brain-gut interactions; (5) expertise in protocol design, data analysis and program development for analysis of electrophysiological traces; and (6) transgenic animals with specific gene mutations through interaction with transgenic Cores within UCLA.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK041301-18
Application #
7415061
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2006-12-01
Project End
2009-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
18
Fiscal Year
2007
Total Cost
$74,473
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Kaji, I; Akiba, Y; Furuyama, T et al. (2018) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol Motil 30:
Kim, Paul H; Luu, Jennings; Heizer, Patrick et al. (2018) Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Sci Transl Med 10:
Dong, Tien S; Aby, Elizabeth S; Benhammou, Jihane N et al. (2018) Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c. World J Hepatol 10:612-621
Chen, Natalie Y; Kim, Paul; Weston, Thomas A et al. (2018) Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Proc Natl Acad Sci U S A 115:10100-10105
Videlock, Elizabeth J; Mahurkar-Joshi, Swapna; Hoffman, Jill M et al. (2018) Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol 315:G140-G157
Zhou, Haoming; Wang, Han; Ni, Ming et al. (2018) Glycogen synthase kinase 3? promotes liver innate immune activation by restraining AMP-activated protein kinase activation. J Hepatol 69:99-109
Larauche, Muriel; Moussaoui, Nabila; Biraud, Mandy et al. (2018) Brain corticotropin-releasing factor signaling: Involvement in acute stress-induced visceral analgesia in male rats. Neurogastroenterol Motil :e13489
Lin, De-Chen; Wang, Ming-Rong; Koeffler, H Phillip (2018) Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology 154:374-389
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Hoffman, Jill M; Sideri, Aristea; Ruiz, Jonathan J et al. (2018) Mesenteric Adipose-derived Stromal Cells From Crohn's Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis. Cell Mol Gastroenterol Hepatol 6:1-16

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