Abstract

The overall goal of the CURE: DDRCC is to promote multidisciplinary research in the molecular and cell biology, physiology and pathophysiology of the digestive system, foster collaboration and facilitate training, education and recruitment of new investigators. The Pilot and Feasibility Studies (PFS) Program, which has been enhanced by partnering with the UCLA Center for Translational Science Institute (CTSI) and by direct institutional resources (see below), is a key component to achieve the goals of the Center. The leverage of PFS funds has provided an important mechanism for enhancing our PFS program via substantial institutional support. We anticipate that a similar enhancement of the PFS program will operate in the next funding period.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK041301-30
Application #
9605776
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
2020-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
30
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Olson, Christine A; Vuong, Helen E; Yano, Jessica M et al. (2018) The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet. Cell 173:1728-1741.e13
Martin, Clair R; Osadchiy, Vadim; Kalani, Amir et al. (2018) The Brain-Gut-Microbiome Axis. Cell Mol Gastroenterol Hepatol 6:133-148
Ehrlich, Dean; Jamaluddin, Nimah; Pisegna, Joseph et al. (2018) A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis. Case Rep Gastrointest Med 2018:9679287
Addante, Raymond; Naliboff, Bruce; Shih, Wendy et al. (2018) Predictors of Health-related Quality of Life in Irritable Bowel Syndrome Patients Compared With Healthy Individuals. J Clin Gastroenterol :
Chen, Wenling; Taché, Yvette; Marvizón, Juan Carlos (2018) Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain. Neuroscience 381:149-158
Gupta, Arpana; Woodworth, Davis C; Ellingson, Benjamin M et al. (2018) Disease-Related Microstructural Differences in the Brain in Women With Provoked Vestibulodynia. J Pain 19:528.e1-528.e15
Marcus, Elizabeth A; Sachs, George; Scott, David R (2018) Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization. Helicobacter 23:e12490
Ziyad, Safiyyah; Riordan, Jesse D; Cavanaugh, Ann M et al. (2018) A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis. Cell Rep 22:1211-1224
Biczo, Gyorgy; Vegh, Eszter T; Shalbueva, Natalia et al. (2018) Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models. Gastroenterology 154:689-703
Salehi, Sahar; Sosa, Rebecca A; Jin, Yi-Ping et al. (2018) Outside-in HLA class I signaling regulates ICAM-1 clustering and endothelial cell-monocyte interactions via mTOR in transplant antibody-mediated rejection. Am J Transplant 18:1096-1109

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