The overall goal of the Administrative Core of the Digestive Diseases Research Core Center (DDRCC) at the University of Chicago is to provide leadership and strategic vision to foster and expand gastrointestinal-related research by its clinical and basic science faculty, particularly in the areas of IBD, and the immunology, inflammation, and microbiology of the GI tract. These themes have defined our GI program ever since Dr. Joseph B Kirsner put forward the hypothesis over 75 years ago that IBD was caused by genetic, immunological, and microbial factors. The goals of the Administrative core are to foster and expand gastrointestinal-related research by its clinical and basic science faculty, particularly in the areas of IBD, and the immunology, inflammation, and microbiology of the GI tract. The core will be responsible for overseeing all aspects of the DDRCC, including strategic, scientific, and operational directions to insure effectiveness and impact of the program. It will continue to seek opportunities to foster interaction and collaborations among its members. Researchers in the DDRCC are now routinely confronted with data sets of significant sizes, requiring the use of clusters, clouds or supercomputers. In anticipation of this growing need, the Administrative Core created the Computational Analysis and Modeling Resource (CAMR) component that a ?one stop shopping? resource to help DDRCC investigators in bioinformatics, biostatistics, high-throughput microbial analysis and modeling & simulation. The CAMR will assist them in the design, execution and interpretation of research projects. The proceedings of the monthly Executive Committee meetings are reviewed on an annual basis by the Internal Advisory Board (comprised of selected senior leaders in the Biological Sciences Division) and the Dean of Biological Sciences, Dr. Kenneth Polonsky. As the neutral review and sounding board, the External Advisory Board (EAB) of the DDRCC reviews all requests, reports, and recommendations of the Executive committee. The members of the EAB include 5 internationally renowned investigators who are leaders in the area of digestive diseases, particularly in the focus areas of the DDRCC. In summary, the Administrative core of the DDRCC provides leadership, strategic and programmatic vision, oversight, and management of a highly multidisciplinary program that foster interaction, collaboration, and synergy in studies of inflammatory bowel diseases and other related inflammatory diseases of the bowel.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK042086-28
Application #
9393992
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
28
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Cockrell, Chase; An, Gary (2017) Sepsis reconsidered: Identifying novel metrics for behavioral landscape characterization with a high-performance computing implementation of an agent-based model. J Theor Biol 430:157-168
Pekow, Joel; Meckel, Katherine; Dougherty, Urszula et al. (2017) miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD. Clin Cancer Res 23:5281-5291
Messer, Jeannette S (2017) The cellular autophagy/apoptosis checkpoint during inflammation. Cell Mol Life Sci 74:1281-1296
An, G; Fitzpatrick, B G; Christley, S et al. (2017) Optimization and Control of Agent-Based Models in Biology: A Perspective. Bull Math Biol 79:63-87
Arvans, Donna; Jung, Yong-Chul; Antonopoulos, Dionysios et al. (2017) Oxalobacter formigenes-Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells. J Am Soc Nephrol 28:876-887
Nobutani, Kentaro; Miyoshi, Jun; Musch, Mark W et al. (2017) Daikenchuto (TU-100) alters murine hepatic and intestinal drug metabolizing enzymes in an in vivo dietary model: effects of gender and withdrawal. Pharmacol Res Perspect 5:
Messer, J S; Liechty, E R; Vogel, O A et al. (2017) Evolutionary and ecological forces that shape the bacterial communities of the human gut. Mucosal Immunol 10:567-579
Nie, Litong; Shuai, Lin; Zhu, Mingrui et al. (2017) The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Mol Cell Proteomics 16:1324-1334
Denzin, Lisa K; Khan, Aly A; Virdis, Francesca et al. (2017) Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity 47:310-322.e7
Alverdy, John C; Luo, James N (2017) The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling. Front Microbiol 8:322

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