application) The primary goal of this Clinical/Tissue Core is to provide tissues and serum from IBD patients to center investigators. The second goal of this core has been to establish a reference database of IBD patients and patient's samples for this center and nationally. This core has developed a customized database that is suitable to document the clinical and laboratory information of the entire IBD population at MGH. Through this database, it is easily to identify the desired patient subgroups and to provide clinical correlation and validation of tissue samples. During the previous funding period, the core service has been expanded to include development of a bank of serum and DNA samples from the IBD patient population. The core will provide the following services for center investigators; 1) clinical database and patient identification. The core will maintain an active clinical database of IBD patients. The investigators with the approved project have access to this database to identify patients needed for study; 2) tissue samples. The core is to provide tissue and serum for center investigator and to establish tissue and serum banks. Investigators needing tissue or serum samples contact the Core director or core technician after the director?s approval; 3) tissue reference bank. In addition to provision of fresh samples of IBD-related tissues and relevant controls, the core has been to store the validated tissue and serum samples for later study; 4) tissue sections. This service has made the core more effective in facilitating the goal of center investigators and make more maximal use of tissue samples; and 5) clinical support and biostatistical analysis. This core will provide the expertise in study design, data base management and analysis for clinical research.

Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
12
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Qu, Chen; Zheng, Dandan; Li, Sai et al. (2018) Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis. Hepatology :
Simon, Tracey G; King, Lindsay Y; Chong, Dawn Q et al. (2018) Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies. Hepatology 67:1797-1806
Borren, Nienke Z; Conway, Grace; Garber, John J et al. (2018) Differences in Clinical Course, Genetics, and the Microbiome Between Familial and Sporadic Inflammatory Bowel Diseases. J Crohns Colitis 12:525-531
Battistone, Maria A; Nair, Anil V; Barton, Claire R et al. (2018) Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells. J Am Soc Nephrol 29:545-556
Imhann, Floris; Vich Vila, Arnau; Bonder, Marc Jan et al. (2018) Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease. Gut 67:108-119
Chandradas, Sajiv; Khalili, Hamed; Ananthakrishnan, Ashwin et al. (2018) Does Obesity Influence the Risk of Clostridium difficile Infection Among Patients with Ulcerative Colitis? Dig Dis Sci 63:2445-2450
Luther, Jay; Gala, Manish; Patel, Suraj J et al. (2018) Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Crohn's Disease Is Not Associated with Emergence of Novel Inflammatory Pathways. Dig Dis Sci 63:738-745
Graham, Daniel B; Luo, Chengwei; O'Connell, Daniel J et al. (2018) Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes. Nat Med 24:1762-1772
Schirmer, Melanie; Franzosa, Eric A; Lloyd-Price, Jason et al. (2018) Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat Microbiol 3:337-346
Cheung, Pui W; Terlouw, Abby; Janssen, Sam Antoon et al. (2018) Inhibition of non-receptor tyrosine kinase Src induces phosphoserine 256-independent aquaporin-2 membrane accumulation. J Physiol :

Showing the most recent 10 out of 1166 publications