This application represents the third competing renewal of the Boston Obesity Nutrition Research Center. The Boston Obesity Nutrition Research Center represents a collaboration of three major universities representing six major organizations, all located within a 1.5 mile radius of one another. The Boston Obesity Center includes Tufts-New England Medical Center, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, Harvard School of Public Health, Boston Medical Center and the Human Nutrition Research Center on Aging. These institutions represent Tufts University, Harvard University and Boston University, respectively The research base has increased from 97 to 163 and includes members from these institutions as well as several new ones, including the University of Massachusetts Boston and the University of Massachusetts Medical School (Worcester) and it affiliated University Center for Excellence in Developmental Disabilities at the Eunice Kennedy Shriver Center in Waltham. The Boston Obesity Nutrition Research Center consists of four Core laboratories. These include an Adipocyte Core directed by Dr. James Kirkland, a Clinical and Community Research Core directed by Dr. Aviva Must, an Epidemiology and Genetics Core directed by Dr. Frank Hu and a Transgenic Core directed by Dr. Bradford Lowell. The Obesity Center offers many opportunities for education and training in obesity research to fellows on training grants held by Obesity Center investigators in each of the collaborating institutions. The investigators represented in this application are Principal Investigators on 171 funded NIH grants, approximately 143 of which are directed at the study of obesity, energy metabolism or other nutritional diseases. In the past five years, the Boston Obesity Center investigators have published 283 papers with Center support. Currently, fifteen percent of the Obesity Center's budget provides support for pilot and feasibility studies. Pilot and feasibility award recipients have published 640 papers and received a total of 41 grants from NIH or other funding agencies based on the data obtained from their Center-funded and subsequent research in obesity and nutrition.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-6 (J1))
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Evans, Mary
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Boston Medical Center
United States
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Mekary, Rania A; Grøntved, Anders; Despres, Jean-Pierre et al. (2015) Weight training, aerobic physical activities, and long-term waist circumference change in men. Obesity (Silver Spring) 23:461-7
Evans, E Whitney; Jacques, Paul F; Dallal, Gerard E et al. (2015) The role of eating frequency on total energy intake and diet quality in a low-income, racially diverse sample of schoolchildren. Public Health Nutr 18:474-81
Gaskins, Audrey Jane; Mendiola, Jaime; Afeiche, Myriam et al. (2015) Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 49:265-70
Zhang, Fang Fang; Roberts, Susan B; Parsons, Susan K et al. (2015) Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention. J Pediatr Hematol Oncol 37:232-6
Lee, Mi-Jeong; Fried, Susan K (2014) Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol 538:49-65
Chavarro, Jorge E; Mínguez-Alarcón, Lidia; Mendiola, Jaime et al. (2014) Trans fatty acid intake is inversely related to total sperm count in young healthy men. Hum Reprod 29:429-40
Ley, Sylvia H; Sun, Qi; Willett, Walter C et al. (2014) Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr 99:352-60
Bao, Wei; Tobias, Deirdre K; Bowers, Katherine et al. (2014) Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study. JAMA Intern Med 174:1047-55
Farvid, Maryam S; Qi, Lu; Hu, Frank B et al. (2014) Phobic anxiety symptom scores and incidence of type 2 diabetes in US men and women. Brain Behav Immun 36:176-82
Huang, Tao; Qi, Qibin; Li, Yanping et al. (2014) FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. Am J Clin Nutr 99:1126-30

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