The Transgenic Core deserves special mention because it has been a critical resource for major advances by BNORC scientists who study the neural control of feeding and reward, a central research question in the obesity field. As summarized in Figure 2, mice engineered with Cre Recombinase activity within specific neurons provide a "gateway" by which to deliver a multitude of "tools", ultimately giving experimenters unprecedented control over any Cre-expressing neurons. BNORC neuroscientist members are at the forefront of the field in applying these powerful technologies, moving the field closer to a wiring diagram for CNS control of feeding behavior, reward/motivation and metabolism. As mentioned above, since neuron-specific Cre-expressing mice enable each of these technologies, the BNORC Transgenic Core serves as a focal point for these activities. Mice developed by the TG core are made available to other researchers nationally and internationally through the Jackson Laboratories, further facilitating a clear impact on the field.

National Institute of Health (NIH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston Medical Center
United States
Zip Code
Mekary, Rania A; Grøntved, Anders; Despres, Jean-Pierre et al. (2015) Weight training, aerobic physical activities, and long-term waist circumference change in men. Obesity (Silver Spring) 23:461-7
Evans, E Whitney; Jacques, Paul F; Dallal, Gerard E et al. (2015) The role of eating frequency on total energy intake and diet quality in a low-income, racially diverse sample of schoolchildren. Public Health Nutr 18:474-81
Gaskins, Audrey Jane; Mendiola, Jaime; Afeiche, Myriam et al. (2015) Physical activity and television watching in relation to semen quality in young men. Br J Sports Med 49:265-70
Zhang, Fang Fang; Roberts, Susan B; Parsons, Susan K et al. (2015) Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention. J Pediatr Hematol Oncol 37:232-6
Lee, Mi-Jeong; Fried, Susan K (2014) Optimal protocol for the differentiation and metabolic analysis of human adipose stromal cells. Methods Enzymol 538:49-65
Chavarro, Jorge E; Mínguez-Alarcón, Lidia; Mendiola, Jaime et al. (2014) Trans fatty acid intake is inversely related to total sperm count in young healthy men. Hum Reprod 29:429-40
Ley, Sylvia H; Sun, Qi; Willett, Walter C et al. (2014) Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr 99:352-60
Bao, Wei; Tobias, Deirdre K; Bowers, Katherine et al. (2014) Physical activity and sedentary behaviors associated with risk of progression from gestational diabetes mellitus to type 2 diabetes mellitus: a prospective cohort study. JAMA Intern Med 174:1047-55
Farvid, Maryam S; Qi, Lu; Hu, Frank B et al. (2014) Phobic anxiety symptom scores and incidence of type 2 diabetes in US men and women. Brain Behav Immun 36:176-82
Huang, Tao; Qi, Qibin; Li, Yanping et al. (2014) FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. Am J Clin Nutr 99:1126-30

Showing the most recent 10 out of 526 publications