The Transgenic Core deserves special mention because it has been a critical resource for major advances by BNORC scientists who study the neural control of feeding and reward, a central research question in the obesity field. As summarized in Figure 2, mice engineered with Cre Recombinase activity within specific neurons provide a "gateway" by which to deliver a multitude of "tools", ultimately giving experimenters unprecedented control over any Cre-expressing neurons. BNORC neuroscientist members are at the forefront of the field in applying these powerful technologies, moving the field closer to a wiring diagram for CNS control of feeding behavior, reward/motivation and metabolism. As mentioned above, since neuron-specific Cre-expressing mice enable each of these technologies, the BNORC Transgenic Core serves as a focal point for these activities. Mice developed by the TG core are made available to other researchers nationally and internationally through the Jackson Laboratories, further facilitating a clear impact on the field.

Agency
National Institute of Health (NIH)
Type
Center Core Grants (P30)
Project #
5P30DK046200-22
Application #
8657035
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
22
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02118
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