The administrative home for the management of this Center and the various participating cores is the Gene Therapy Program of the Division of Transfusion Medicine of the Department of Pathology and Lab Animal Medicine which is headed by the PI of this grant, Dr. James M. Wilson. The Dean of the Medical School provides financial support to this program. Dr. Maria Limberis the Gene Therapy Department is the Co-Pi of the grant and Ms. Kelly D. Reynolds, who is the Director of Finance and Operations for the Gene Therapy Program, provides all administrative support for the activities of the Center. A number of administrative vehicles are in place to assure the Center and its participating cores meet the objectives of the program. Independent weekly core management meetings are held to review activities of the cores including the following: Vector and Immunology Core Management meeting, Cell Morphology Management meeting, and Animal Models Core Management meeting. Internal and External Oversight Committees are in place to review the activities of the Center. The Gene Therapy Program coordinates a Gene Therapy Seminar Series which is partially sponsored by this Center. Finally, the Administrative Core oversees all aspects of the Pilot and Feasibility Program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK047757-20
Application #
8448741
Study Section
Special Emphasis Panel (ZDK1-GRB-1)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
20
Fiscal Year
2013
Total Cost
$250,179
Indirect Cost
$84,905
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Baek, Jeong-In; Choi, Soo Young; Chacon-Heszele, Maria F et al. (2014) Expression of Drosophila forkhead transcription factors during kidney development. Biochem Biophys Res Commun 446:15-7
Adam, Virginie S; Crosariol, Marco; Kumar, Sachin et al. (2014) Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus. Clin Vaccine Immunol 21:1528-33
Xiao, Yan; Nagai, Yasuhiro; Deng, Guoping et al. (2014) Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep 7:1471-80
Chacon-Heszele, Maria F; Zuo, Xiaofeng; Hellman, Nathan E et al. (2014) Novel MAPK-dependent and -independent tubulogenes identified via microarray analysis of 3D-cultured Madin-Darby canine kidney cells. Am J Physiol Renal Physiol 306:F1047-58
Mays, Lauren E; Wang, Lili; Lin, Jianping et al. (2014) AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Mol Ther 22:28-41
Nagai, Y; Limberis, M P; Zhang, H (2014) Modulation of Treg function improves adenovirus vector-mediated gene expression in the airway. Gene Ther 21:219-24
O'Neill, S M; Hinkle, C; Chen, S-J et al. (2014) Targeting adipose tissue via systemic gene therapy. Gene Ther 21:653-61
Huang, Liwei; Lipschutz, Joshua H (2014) Cilia and polycystic kidney disease, kith and kin. Birth Defects Res C Embryo Today 102:174-85
Myint, Melissa; Limberis, Maria P; Bell, Peter et al. (2014) In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection. Hum Gene Ther 25:966-76
Bryant, Laura M; Christopher, Devin M; Giles, April R et al. (2013) Lessons learned from the clinical development and market authorization of Glybera. Hum Gene Ther Clin Dev 24:55-64

Showing the most recent 10 out of 206 publications