Abstract

The Gene Therapy Core Center (GTCC) proposed for the University of California, San Francisco Medical School will be directed by Dr. Y.W. Kan and be centered around a three-component Research Base: 1) cystic fibrosis (CF), 2) hematologic, and 3) metabolic and cellular. The primary focus of the center will be CF. The GTCC will be composed of four biomedical cores: 1) Animal Model, 2) Cell Biology, 3) Molecular Biology, and 4) Gene Transfer Vehicle. In addition, the GTCC will have an Administrative Component that will administer the grant and be directly responsible for the administration of the Pilot and Feasibility (P&F) Program and an Enrichment Program. The P&F Program will be comprised of CF and non CF projects. At present eight projects have been included (seven CF and 1 non CF).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK047766-02
Application #
2147604
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1994-09-16
Budget End
1995-08-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Pathology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Hawgood, Samuel; Ochs, Matthias; Jung, Anja et al. (2002) Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol 283:L1002-10
Lalwani, Anil K; Han, Jay J; Castelein, Caley M et al. (2002) In vitro and in vivo assessment of the ability of adeno-associated virus-brain-derived neurotrophic factor to enhance spiral ganglion cell survival following ototoxic insult. Laryngoscope 112:1325-34
Xu, Z; Jablons, D M; Gruenert, D C (2001) Expression sequence tag-specific full-length cDNA cloning: actin cDNAs. Gene 263:265-72
Gum Jr, J R; Hicks, J W; Gillespie, A M et al. (2001) Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi. Cancer Res 61:3472-9
Colosimo, A; Goncz, K K; Novelli, G et al. (2001) Targeted correction of a defective selectable marker gene in human epithelial cells by small DNA fragments. Mol Ther 3:178-85
Goncz, K K; Colosimo, A; Dallapiccola, B et al. (2001) Expression of DeltaF508 CFTR in normal mouse lung after site-specific modification of CFTR sequences by SFHR. Gene Ther 8:961-5
Colosimo, A; Goncz, K K; Holmes, A R et al. (2000) Transfer and expression of foreign genes in mammalian cells. Biotechniques 29:314-8, 320-2, 324 passim
Camargo, F D; Huey-Louie, D A; Finn, A V et al. (2000) Germline incorporation of a replication-defective adenoviral vector in mice does not alter immune responses to adenoviral vectors. Mol Ther 2:496-504
Hirota, S; de Ilarduya, C T; Barron, L G et al. (1999) Simple mixing device to reproducibly prepare cationic lipid-DNA complexes (lipoplexes). Biotechniques 27:286-90
Holmes, A R; Dohrman, A F; Ellison, A R et al. (1999) Intracellular compartmentalization of DNA fragments in cultured airway epithelial cells mediated by cationic lipids. Pharm Res 16:1020-5

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