Abstract

The overall theme of the Metabolic Core lab is to support investigation of insulin resistance, obesity, and inflammation from a cellular/molecular perspective. The Metabolic Core provides consultation and analysis of insulin signaling, hormone assays, qPCR, insulin clamping (mice, rats), and cell based assays of cytokines and adipokines tailored to the investigators needs. Over the last grant period the Metabolic Core has developed expertise in multiplex based cytokine analysis. Most recently the Metabolic Core received NIH funding to purchase a Seahorse XF24-3 extracellular flux analyzer to allow us to begin to interrogate mitochondrial function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-18
Application #
8379792
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
18
Fiscal Year
2012
Total Cost
$228,823
Indirect Cost
$75,549

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Bjornstad, Petter; Cree-Green, Melanie; Baumgartner, Amy et al. (2018) Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtform Pediatr Diabetes 19:436-442
Cintron, Dahima; Lahr, Brian D; Bailey, Kent R et al. (2018) Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Menopause 25:145-153
Hill, Jessica H; Solt, Claudia; Foster, Michelle T (2018) Obesity associated disease risk: the role of inherent differences and location of adipose depots. Horm Mol Biol Clin Investig 33:
Estrada, Andrea Lee; Hudson, William Max; Kim, Paul Y et al. (2018) Short-term changes in diet composition do not affect in vivo hepatic protein synthesis in rats. Am J Physiol Endocrinol Metab 314:E241-E250
Hohos, Natalie M; Cho, Kirstin J; Swindle, Delaney C et al. (2018) High-fat diet exposure, regardless of induction of obesity, is associated with altered expression of genes critical to normal ovulatory function. Mol Cell Endocrinol 470:199-207
Martens, Christopher R; Denman, Blair A; Mazzo, Melissa R et al. (2018) Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 9:1286
Hegde, Nagaraj; Bries, Matthew; Swibas, Tracy et al. (2018) Automatic Recognition of Activities of Daily Living Utilizing Insole-Based and Wrist-Worn Wearable Sensors. IEEE J Biomed Health Inform 22:979-988
Cree-Green, Melanie; Scalzo, Rebecca L; Harrall, Kylie et al. (2018) Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes 67:1369-1379
Mintz, Michael; Khair, Shanawaj; Grewal, Suman et al. (2018) Longitudinal microbiome analysis of single donor fecal microbiota transplantation in patients with recurrent Clostridium difficile infection and/or ulcerative colitis. PLoS One 13:e0190997
Lee, Dustin M; Battson, Micah L; Jarrell, Dillon K et al. (2018) SGLT2 inhibition via dapagliflozin improves generalized vascular dysfunction and alters the gut microbiota in type 2 diabetic mice. Cardiovasc Diabetol 17:62

Showing the most recent 10 out of 756 publications