The USC Research Center for Liver Disease (RCLD), which was founded in 1995, is dedicated to fostering and facilitating the collaborative research of its 57 current members and the career development of junior faculty through provision of research technologies and fora for scientific exchange. Thirty-seven members contribute to a stable research base in excess of ten million dollars annually with a growing translational emphasis.
The Specific Aims of the USC Research Center for Liver Disease are: 1) To provide the essential services offered by Biomedical Core facilities to facilitate the research of the membership to advance our understanding of the pathogenesis and treatment of liver and digestive disease; 2) To foster collaboration between Center members through the use of Cores, the enrichment program, and the Special Interest group; 3) To foster career development through availability of Biomedical Cores, enrichment program, and pilot/feasibility support and attract the talents of established investigators from other fields to apply their expertise to liver and digestive disease research and to collaborate with Center members; 4) Facilitate the technological training and scientific development of postdoctoral fellows, K awardees and junior faculty through the services of the scientific cores, the enrichment program and pilot funding. The RCLD serves as the focal point for the interaction of a large number of faculty conducting research to advance our understating of the pathogenesis, prevention and treatment of liver diseases. The Center focuses on research in Liver Disease with 4 major themes: 1) viral hepatitis and liver cancer, 2) steatohepatitis and fibrosis, 3) hepatotoxicity and mitochondrial pathobiology, 4) repair, regenerative medicine and developmental biology. The Center supports an Administrative Core, the hub for all Center activities, includes the Center Director [Kaplowitz], Associate Director [DeLeve], and Assistant Director [Ookhtens], Administrator [Vidrio], who constitute the Operations Committee, as well as an Executive Committee and External Scientific Advisory Board. The Enrichment Program sponsors seminars, an annual symposium and research mini-symposia. The Pilot/Feasibility Project Program preferentially funds innovative new projects of young investigators which are relevant to the Center's themes. The Center has four scientific Cores: 1) Cell and Tissue Imaging (advanced microscopy), 2) Liver Histology (routine, special stains and immunohistochemistry), 3) Cell Separation and Culture (fluorescent cell sorting and liver cell culture), 4) Analytical (HPLC services), Metabolic (mitochondrial function), Instrumentation (shared central core equipment), and Proteomics Core (mass spectrometry).

Public Health Relevance

Acute and chronic liver diseases due to viral hepatitis and alcoholic and non-alcoholic steatohepatitis represents a major public health problem with serious outcomes such as acute liver failure, cirrhosis, and liver cancer leading to major economic costs and loss of life. The USC Research Center for Liver Disease has the goal of facilitating and fostering cutting edge science and its clinical translation to advance the diagnosis and treatment of liver diseases

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048522-23
Application #
9414639
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Perrin, Peter J
Project Start
1997-03-01
Project End
2021-02-28
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
23
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Tomita, Kyoko; Kohli, Rohit; MacLaurin, Brittany L et al. (2017) Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis. JCI Insight 2:
Matsushita, Noriko; Hassanein, Mohamed T; Martinez-Clemente, Marcos et al. (2017) Gender difference in NASH susceptibility: Roles of hepatocyte Ikk? and Sult1e1. PLoS One 12:e0181052
Lee, Amy S; Brandhorst, Sebastian; Rangel, Daisy F et al. (2017) Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep 7:40919
Elmasry, Sandra; Wadhwa, Sanya; Bang, Bo-Ram et al. (2017) Detection of Occult Hepatitis C Virus Infection in Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents for Recurrent Infection After Liver Transplantation. Gastroenterology 152:550-553.e8
Alonso, Cristina; Fernández-Ramos, David; Varela-Rey, Marta et al. (2017) Metabolomic Identification of Subtypes of Nonalcoholic Steatohepatitis. Gastroenterology 152:1449-1461.e7
Sakiyama, Ryoichi; Blau, Brandon J; Miki, Toshio (2017) Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells. World J Gastroenterol 23:1974-1979
Moeini, Aida; Machida, Hiroko; Takiuchi, Tsuyoshi et al. (2017) Association of Nonalcoholic Fatty Liver Disease and Venous Thromboembolism in Women With Endometrial Cancer. Clin Appl Thromb Hemost 23:1018-1027
Pyzik, Michal; Rath, Timo; Kuo, Timothy T et al. (2017) Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury. Proc Natl Acad Sci U S A 114:E2862-E2871
Dhandhukia, Jugal P; Li, Zhe; Peddi, Santosh et al. (2017) Berunda Polypeptides: Multi-Headed Fusion Proteins Promote Subcutaneous Administration of Rapamycin to Breast Cancer In Vivo. Theranostics 7:3856-3872
Johnson, Sandra A S; Lin, Justin J; Walkey, Christopher J et al. (2017) Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer. Oncotarget 8:48832-48845

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