of the Core The Molecular Pathology and Imaging Core (MPIC) was established in 1995 as the """"""""Morphology Core,"""""""" as part of the Program Project """"""""Differentiation of Tissues Involved in Nutrition and Metabolism"""""""" (DK049210). In 1997, MPIC expanded to provide services and reagents to investigators (i.e. members and associate members) of the Center for Molecular Studies in Digestive and Liver Disease (CMSDLD;P30DK50306) and, in 2003, became part of an additional Program Project, """"""""Mechanisms of Esophageal Carcinogenesis"""""""" (CA098101). The additional funding through the CMSDLD and the second P01 allowed MPIC to grow significantly by expanding services, equipment, space, and personnel, with tremendous benefits, as detailed below, to CMSDLD investigators. The name change, instituted this year, reflects a marked expansion of Core services and equipment. Through the years. MPIC has remained independent, rather than become an open, school-wide facility, in order to preserve focus and serve the needs of its dedicated clientele. Thus, use of the facility is restricted to CMSDLD investigators and investigators of the two P01s. Currently, MPIC comprises 4 rooms and 1153 square feet (Figure 1) on the 6""""""""^ floor of the Clinical Research Building (CRB), adjacent to many of the GI research laboratories;a recent addition expanded the size of MPIC by more than 70%. MPIC now includes the following: ? two large laboratories (CRB 602 and 675) with 8 total benches and 2 chemical hoods, each containing a complete set-up for performing in-core immunohistochemistry (IHC), immunofluorescence (IF), and in-situ hybridization (ISH) ? a tissue processing room (CRB 61 OB) with a chemical hood ? an adjacent small room (CRB 608) housing the confocal microscope and laser capture micro-dissection (LCM) apparatus. ? office space (adjoining CRB 675) for the technical director with computer and telecommunications MPIC has been extremely successful since its inception, has been heavily utilized, and has served as a model core facility for numerous other program projects and centers both at the University of Pennsylvania and throughout the country. Moreover, MPIC has continually improved its ability to provide quality services in a timely manner to CMSDLD investigators. MPIC assesses nominal charges for tissue processing and sectioning, special staining, confocal microscopy, and laser capture microdissection;all other core services are available at no cost to CMSDLD investigators and their laboratories;MPIC services are particularly valuable to associate members, many of whom do not yet have independent funding, and Pilot and Feasibility (P/F) awardees. MPIC was reviewed recently through the competitive renewals of the two supporting P01 grants (P01 DK049210 was reviewed in 2008 and P01 DK049210 in 2011) and was judged to be exceptional in both cases. For example, in the most recent review in 2011

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1-GRB-8)
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University of Pennsylvania
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Zhou, Jin; Wu, Zhong; Wong, Gabrielle et al. (2017) CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma. Nat Commun 8:13897
Whelan, K A; Chandramouleeswaran, P M; Tanaka, K et al. (2017) Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene 36:4843-4858
Long, Kristen B; Tooker, Graham; Tooker, Evan et al. (2017) IL6 Receptor Blockade Enhances Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther 16:1898-1908
Mukherjee, Sarmistha; Chellappa, Karthikeyani; Moffitt, Andrea et al. (2017) Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration. Hepatology 65:616-630
Boursi, Ben; Finkelman, Brian; Giantonio, Bruce J et al. (2017) A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-Onset Diabetes. Gastroenterology 152:840-850.e3
Whelan, Kelly A; Merves, Jamie F; Giroux, Veronique et al. (2017) Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis. Gut 66:1197-1207
Di Bisceglie, A M; Lombardero, M; Teckman, J et al. (2017) Determination of hepatitis B phenotype using biochemical and serological markers. J Viral Hepat 24:320-329
Carr, Rotonya M; Dhir, Ravindra; Mahadev, Kalyankar et al. (2017) Perilipin Staining Distinguishes Between Steatosis and Nonalcoholic Steatohepatitis in Adults and Children. Clin Gastroenterol Hepatol 15:145-147
Chowdhury, A Roy; Long, A; Fuchs, S Y et al. (2017) Mitochondrial stress-induced p53 attenuates HIF-1? activity by physical association and enhanced ubiquitination. Oncogene 36:397-409
Harmeyer, Kayla M; Facompre, Nicole D; Herlyn, Meenhard et al. (2017) JARID1 Histone Demethylases: Emerging Targets in Cancer. Trends Cancer 3:713-725

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