of the Core The Molecular Pathology and Imaging Core (MPIC) was established in 1995 as the """"""""Morphology Core,"""""""" as part of the Program Project """"""""Differentiation of Tissues Involved in Nutrition and Metabolism"""""""" (DK049210). In 1997, MPIC expanded to provide services and reagents to investigators (i.e. members and associate members) of the Center for Molecular Studies in Digestive and Liver Disease (CMSDLD;P30DK50306) and, in 2003, became part of an additional Program Project, """"""""Mechanisms of Esophageal Carcinogenesis"""""""" (CA098101). The additional funding through the CMSDLD and the second P01 allowed MPIC to grow significantly by expanding services, equipment, space, and personnel, with tremendous benefits, as detailed below, to CMSDLD investigators. The name change, instituted this year, reflects a marked expansion of Core services and equipment. Through the years. MPIC has remained independent, rather than become an open, school-wide facility, in order to preserve focus and serve the needs of its dedicated clientele. Thus, use of the facility is restricted to CMSDLD investigators and investigators of the two P01s. Currently, MPIC comprises 4 rooms and 1153 square feet (Figure 1) on the 6""""""""^ floor of the Clinical Research Building (CRB), adjacent to many of the GI research laboratories;a recent addition expanded the size of MPIC by more than 70%. MPIC now includes the following: ? two large laboratories (CRB 602 and 675) with 8 total benches and 2 chemical hoods, each containing a complete set-up for performing in-core immunohistochemistry (IHC), immunofluorescence (IF), and in-situ hybridization (ISH) ? a tissue processing room (CRB 61 OB) with a chemical hood ? an adjacent small room (CRB 608) housing the confocal microscope and laser capture micro-dissection (LCM) apparatus. ? office space (adjoining CRB 675) for the technical director with computer and telecommunications MPIC has been extremely successful since its inception, has been heavily utilized, and has served as a model core facility for numerous other program projects and centers both at the University of Pennsylvania and throughout the country. Moreover, MPIC has continually improved its ability to provide quality services in a timely manner to CMSDLD investigators. MPIC assesses nominal charges for tissue processing and sectioning, special staining, confocal microscopy, and laser capture microdissection;all other core services are available at no cost to CMSDLD investigators and their laboratories;MPIC services are particularly valuable to associate members, many of whom do not yet have independent funding, and Pilot and Feasibility (P/F) awardees. MPIC was reviewed recently through the competitive renewals of the two supporting P01 grants (P01 DK049210 was reviewed in 2008 and P01 DK049210 in 2011) and was judged to be exceptional in both cases. For example, in the most recent review in 2011

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK050306-17
Application #
8441493
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
17
Fiscal Year
2013
Total Cost
$187,548
Indirect Cost
$70,330
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wangensteen, Kirk J; Wang, Yue J; Dou, Zhixun et al. (2018) Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology 68:663-676
Andres, Sarah F; Williams, Kathy N; Rustgi, Anil K (2018) The Molecular Basis of Metastatic Colorectal Cancer. Curr Colorectal Cancer Rep 14:69-79
Serper, M; Forde, K A; Kaplan, D E (2018) Rare clinically significant hepatic events and hepatitis B reactivation occur more frequently following rather than during direct-acting antiviral therapy for chronic hepatitis C: Data from a national US cohort. J Viral Hepat 25:187-197
Avetisyan, Marina; Rood, Julia E; Huerta Lopez, Silvia et al. (2018) Muscularis macrophage development in the absence of an enteric nervous system. Proc Natl Acad Sci U S A 115:4696-4701
Kim, Yong Hoon; Marhon, Sajid A; Zhang, Yuxiang et al. (2018) Rev-erb? dynamically modulates chromatin looping to control circadian gene transcription. Science 359:1274-1277
Costea, Paul I; Hildebrand, Falk; Arumugam, Manimozhiyan et al. (2018) Enterotypes in the landscape of gut microbial community composition. Nat Microbiol 3:8-16
Khalili, Mandana; Shuhart, Margaret C; Lombardero, Manuel et al. (2018) Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B. Diabetes Care 41:1251-1259
Correnti, Jason M; Gottshall, Lauren; Lin, Annie et al. (2018) Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells. Sci Rep 8:12923
Shoshkes-Carmel, Michal; Wang, Yue J; Wangensteen, Kirk J et al. (2018) Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature 557:242-246
Qiu, Chengxiang; Huang, Shizheng; Park, Jihwan et al. (2018) Renal compartment-specific genetic variation analyses identify new pathways in chronic kidney disease. Nat Med 24:1721-1731

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