The Washington University DDRCC is integrated with the NIH's Clinical Translational Science Award (CTSA) sponsored Washington University Institute of Clinical Translational Sciences (ICTS), primarily through the Clinical Component ofthe DDRCC and the ICTS Centerfor Biomedical Informatics. The DDRCC Clinical Component is primarily focused on providing investigators with access to clinical samples for digestive diseases related research. The collection and maintenance of clinical samples linked to longitudinal clinical information in a manner that is responsive to our DDRCC investigators, requires a high level of clinical expertise in accurately phenotyping the patient subjects and a high level of stringent oversight in collecting clinical samples. For this reason, organization of tissue procurement at this institution has moved away from a single monolithic institutional unit attempting to collect a broad array of clinical samples from patients with many different diseases. Instead, tissue procurement is being conducted by smaller disease focused units, such as the DDRCC sponsored facility, that are linked to each other by a common biomedical informatics platforms (Tissue Suite and ClinPortal) developed and maintained by the CTSA-sponsored Center for Biomedical Informatics. Furthermore, the data output from two of the Research Core Facilities, the Functional Genomics Core and the Proteomics Core are in the process of being uploaded to databases (Profile DB) maintained by the ICTS Center for Biomedical Informatics.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK052574-15
Application #
8574506
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
15
Fiscal Year
2014
Total Cost
$452,726
Indirect Cost
$154,881
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Zhang, Daoxiang; Li, Lin; Jiang, Hongmei et al. (2017) Constitutive IRAK4 Activation Underlies Poor Prognosis and Chemoresistance in Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 23:1748-1759
Knoop, Kathryn A; Gustafsson, Jenny K; McDonald, Keely G et al. (2017) Antibiotics promote the sampling of luminal antigens and bacteria via colonic goblet cell associated antigen passages. Gut Microbes 8:400-411
Sáenz, José B; Mills, Jason C (2017) Biological techniques: Stomach growth in a dish. Nature 541:160-161
Feng, Jing; Yang, Pu; Mack, Madison R et al. (2017) Sensory TRP channels contribute differentially to skin inflammation and persistent itch. Nat Commun 8:980
Burclaff, Joseph; Osaki, Luciana H; Liu, Dengqun et al. (2017) Targeted Apoptosis of Parietal Cells Is Insufficient to Induce Metaplasia in Stomach. Gastroenterology 152:762-766.e7
Lu, Zhi Hong; Kaliberov, Sergey; Sohn, Rebecca E et al. (2017) A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector. Oncotarget 8:12272-12289
Elo, Teresa; Lindfors, Päivi H; Lan, Qiang et al. (2017) Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Sci Rep 7:5049
Barron, Lauren K; Warner, Barbara B; Tarr, Phillip I et al. (2017) Independence of gut bacterial content and neonatal necrotizing enterocolitis severity. J Pediatr Surg 52:993-998
Radyk, Megan D; Burclaff, Joseph; Willet, Spencer G et al. (2017) Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells. Gastroenterology :
Oetjen, Landon K; Mack, Madison R; Feng, Jing et al. (2017) Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch. Cell 171:217-228.e13

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